降钙素原在综合ICU的成本研究

Application of procalciton in comprehensive ICU

目的:分析ICU中抗生素在治疗感染患者时降钙素原(PCT)的成本及效果。方法:将112例感染者随机均分为2组,治疗组采用PCT指导法抗感染,对照组采用常规指导法抗感染,对2组抗感染治疗的直接医疗成本及效果进行评价。结果:2组的人均监测费用、指导抗菌启动时间、监测有效率差异有统计学意义(P<0.05或0.01),人均总成本、人均抗生素费用、继发真菌发生率、耐药菌发生率、副反应总发生率、治疗好转率、治疗恶化率等差异均无统计学意义。结论:PCT指导抗感染疗效较好,但是效果成本比低,从而无法取代效果成本高、疗效好的常规指导抗生素治疗的地位。

Objective：Analysis of the cost-effectiveness of procalcitonin（PCT）in the treatment of infected patients in ICU settings. Method： 112 cases were divided into two groups at random. The treatment group was treated according to the PCT guidance law against infection. The control group was treated according to conventional anti infective guidance. The direct medical cost of two groups and effect were evaluated and compared. Result： The monitoring cost per capita,start time of antibacterial guiding and monitoring efficiency had statistically significance （P〈0.05 or 0.01）. The total cost per capita,cost of antibiotics per capita,the incidence of secondary fungus,incidence of drug-resistant bacteria, the total incidence, the treatment rate of deterioration had no statistical significance （P〈0.05）. Conclusion：The effect of PCT guidance of anti-infection is good, but the cost-effectiveness was low.