抑郁症患者血清脑源性神经营养因子水平测定及临床意义

The determination and clinical implications of serum brain-derived neurotrophic factor level in depressive patients

目的：探讨抑郁症患者血清脑源性神经营养因子（ BDNF）水平及其与性别、年龄、发病年龄、病程、抑郁严重程度的关系。方法采用酶联免疫分析实验双抗体夹心法测定91例抑郁症患者和36名健康对照者血清BDNF水平，并以汉密顿抑郁量表（ HAMD）评定抑郁症患者的严重程度。结果抑郁症患者组血清BDNF水平为（24．38±6．27）μg/L，低于对照组的（31．44±10．72）μg/L（ t＝3．708，P＜0．01）。抑郁症患者血清BDNF水平与年龄、性别、发病年龄、病程、抑郁严重程度不相关（r＝-0．034、t＝0．068、r＝-0．025、0．026、-0．076，均P＞0．05）。结论抑郁症患者血清BDNF降低，并提示这可能是抑郁症的一个状态特征。

Objective To explore the serum levels of brain-derived neurotrophic factor in patients with depression and their correlation with age,gender,age of onset,illness course,depressive severity.Methods Serum BDNF levels in 91 depressive patients and 36 healthy controls were assayed by the ELISA method .The clinical char-acteristics were assessed by the Hamilton Rating Scale for Depression （ HAMD） .Results The serum BDNF levels in depressive patients were （24.38 ±6.27）μg/L,which was significantly lower than （31.44 ±10.72）μg/L in controls （t=3.708,P 〈0.01） and were unrelated to age,gender,age of onset,illness course,depressive severity （r =-0.034,t=0.068,r =-0.025,0.026, -0.076,P 〉0.05）.Conclusion Serum BDNF levels in depressive patients was decreased and low levels of BDNF in serum may be a state characteristic for depression .