来曲唑方案用于不同年龄多囊卵巢综合征患者促排卵疗效比较

Comparison of Letrozol regimen for ovulation induction in elderly or younger patients with polycystic ovary syndrome

目的：比较来曲唑方案对不同年龄多囊卵巢综合征（ PCOS）促排卵的临床疗效。方法回顾性分析来曲唑（ LE）方案促排卵治疗的56例PCOS患者资料共68个周期。按年龄分为高龄组（≥35岁）、低龄组（≤28岁）。比较HCG注射日两组患者子宫内膜厚度、形态、优势卵泡数、排卵数及妊娠率。结果高龄组与低龄组相比，子宫内膜厚度为（7．9±1．7）mm 与（9．4±3．2）mm，差异有统计学意义（t＝2．648，P＜0.05），AB型子宫内膜率71．9％与77．8％、优势卵泡数（1．5±1．5）个与（1．4±1．2）个、排卵数个（1．3±0．8）个与（1．4±1.2）个，妊娠率（37．5％与27．8％）差异无统计学意义（ t＝2．456、1．995、1．758、1．525，均P＞0.05）。结论 LE方案对不同年龄PCOS患者同样有效，虽然高龄患者子宫内膜厚度低于年轻患者，但优势卵泡数、形态、排卵数无别，并不降低其妊娠率。

Objective To compare the efficacy of Letrozol （ LE） regimen for ovulation induction in elderly and younger patients with polycystic ovary syndrome （PCOS）.Methods A total of 67 ovulation induction cycle by LE regimen in patients elderly than 35 years old or younger than 28 years old with PCOS were studied .The endometrial thickness,morphology,number of dominant follicles,ovulation on the day of injection HCG and pregnancy outcome were recorded.Results The endometrial thickness were significantly different between the two groups [（7.9 ±1.7） mm vs （9.4 ±3.2）mm,t=2.648,P〈0.05],but the endometrial morphology of AB type ,the number of dominant follicles and ovulation,pregnancy rate were indifferent [71.9% vs 77.8%,（1.5 ±1.5） vs （1.4 ±1.2）,（1.3 ± 0.8） vs （1.4 ±1.2）,37.5%vs 27.8%,t=2.456,1.995,1.758,1.525,all P〉0.05].Conclusion LE regimen for ovulation induction is effective for PCOS patients of all ages ,although the elderly patients with endometrial thick-ness is less than that in younger ones .The number of dominant follicles ,endometrial morphology and ovulation is no different,don′t reduce pregnancy rates .