恩替卡韦联合六味五灵片治疗乙型肝炎病毒e抗原阳性慢性乙型肝炎的临床观察

Clinical observation of Entecavir combined Liuweiwuling Pian in the treatment of chronic hepatitis B patients with HBeAg ＋

目的探讨恩替韦卡（ETV）联合六味五灵片治疗乙型肝炎病毒e抗原阳性慢性乙型肝炎的疗效和安全性。方法将124例乙型肝炎病毒e抗原阳性慢性乙型肝炎患者采用随机数字表法分为两组，分别采用ETV联合六味五灵片治疗和单纯ETV治疗，比较两组肝功能及病毒复制指标。结果观察组有效率91．94％，对照组有效率82．26％，两组差异有统计学意义（Ridit=32．251，P〈0．05）；治疗24周、48周，观察组HBVDNA低于对照组，差异有统计学意义（t=2．365、4．595，均P〈0．05）；治疗后，观察组ALT、AST下降程度显著大于对照组（t=78．512、62．145，均P〈0．05）；治疗后两组ALT复常率、总有效率和反跳率差异均有统计学意义（x^2=25．621、46．241、11．512，均P〈0．05），HBVDNA和HBeAg阳性低于检测下限例数差异具有统计学意义（x^2=17．265、21．264，均P〈0．05）。结论恩替韦卡联合六味五灵片治疗乙型肝炎病毒e抗原阳性慢性乙型肝炎能够减轻肝脏纤维化．并具有明显解毒和抗病毒作用。

Objective To explore the curative effect and safety of of Entecavir（ETV） combined Liuweiwuling Pian in the treatment of chronic hepatitis B patients with HBeAg ＋. Methods 124 patients according to the random number table were divided into the two groups, which respectively used ETV combined Liuweiwuling Pian treat- ment and ETV. The liver function and index of viral replication of the two groups were compared. Results The effectiveness of the observation group was 91.94% ,which of the control group was 82.26% ,the difference between the two groups had statistical significance（ Ridit = 32. 251 ,P = 0. 000） ;Since 24 week treatment, HBV DNA of the observa tion group was lower than the control group, the difference was statistically significant （ t = 2. 365,4. 595, all P 〈 0. 05 ） ;After treatment, ALT, AST of the observation group decreasing degree was higher than the control group, the difference was statistically significant （ t = 78.512,62. 145, all P 〈 0.05 ） ; after treatment, the ALT rate, effective rate and bounce rate in the two groups was statistically significant differences （x^2= 25. 621,46. 241,11. 512, all P 〈 0. 05 ） ;After treatment,the HBV DNA and HBeAg positive in two groups was below cut-off test cases, differences was statistically significant（ x^2 = 17. 265,21. 264, all P 〈 0.05 ）. Conclusion Entecavir combined Liuweiwuling Pian in the treatment of chronic hepatitis B patients with HBeAg ＋ can reduce liver fibrosis, and has obvious detoxification and anti-viral.