老年急性心肌梗死患者血清超敏C反应蛋白、尿酸水平与病情的相关性研究

Correlation study of serum hs-CRP, UA level and the correlation of disease in elderly acute myocardial infarction patients

目的：探讨老年急性心肌梗死患者血清超敏C反应蛋白（hsCRP）、尿酸（UA）水平与病情的相关性，为临床预测病情发展及预后提供参考依据。方法选取40例老年急性心肌梗死患者作为研究对象，根据入院时间顺序按比例随机选取同期收治的40例不稳定型心绞痛老年患者、40例稳定型心绞痛老年患者、40例门诊体检正常健康老年人为对照。检测血清hsCRP、UA并进行相关性分析。结果血清hsCRP、UA心肌梗死组为（34．67±12．18） mg/L、（412．46±68．93）μmol/L，不稳定型心绞痛组为（17．21±8．39） mg/L、（274．19±46．62）μmol/L，稳定型心绞痛组为（5．25±1．40） mg/L、（297．41±37．43）μmol/L，健康组为（4.96±1．24）mg/L、（279．64±34．78）μmol/L，心肌梗死组、不稳定型心绞痛、稳定型心绞痛组间差异有统计学意义（P＜0．05），心肌梗死组与健康组差异有统计学意义（P＜0．05）；心肌梗死患者预后不良组hsCRP、UA明显高于预后良好组（P＜0．05）；心肌梗死组、不稳定型心绞痛组hsCRP与UA间存在正相关（P＜0．05），稳定型心绞痛组无相关性（P＞0．05）；不同预后心肌梗死患者hsCRP与UA呈正相关（P＜0．05）。结论老年急性心肌梗死患者血清hsCRP、UA明显升高，与病情发展相关性，高水平的hsCRP、UA常预示患者预后不良。

Objective To investigate correlation study of serum hs-CRP,UA level and the correlation of dis-ease in elderly acute myocardial infarction patients , and provide a reference basis for clinical judgment for patients with illness development and prognosis prediction .Methods 40 aged patients with acute myocardial infarction pa-tients were selected as the research object ,and protionally random according to time admission the same period ran-domly selected were 40 cases of elderly patients with unstable angina pectoris ,40 cases of elderly patients with stable angina,40 cases of clinic medical normal healthy old people for controlled object .The levels of serum hs-CRP,UA and correlation was analyzed.Results The serum hsCRP,UA in the myocardial infarction group were （34.67 ±12.18）mg/L, （412.46 ±68.93）μmol/L,which in the unstable angina pectoris group were （17.21 ±8.39） mg/L,（274.19 ± 46.62）μmol/L,which in stable angina pectoris group were （5.25 ±1.40） mg/L,（297.41 ±37.43）μmol/L,which in the health group（4.96 ±1.24）mg/L,（279.64 ±34.78）μmol/L,the differences among the myocardial infarction group,unstable angina pectoris,stable angina pectoris group had statistical significance （P〈0.05）, the differences between myocardial infarction group and health group had statistical significance （P〈0.05）;Myocardial infarction patients prognosis group hs-CRP,UA group was obviously higher than that of the prognosis was good ,compared with statistical significance difference （ P 〈0.05 ）;In myocardial infarction group , unstable angina pectoris group , the hsCRP was associated with positive correlation exists between UA （P〈0.05）,stable angina pectoris group no correla-tion（P〉0.05）;Different prognosis in patients with myocardial infarction hsCRP is associated with UA has positive correlation between （ P〈0.05） .Conclusion Elderly acute myocardial infarction patients serum hs-CRP,UA obviously increased ,and illness development correlation ,a high level of hs-CRP,UA patients often indicates poor prognosis .