高强度超声聚焦刀治疗子宫肌瘤的有效性及安全性探讨

Investigation on the effect and safety of high-intensity focused ultrasound in treating uterine fibroids

目的：观察高强度超声聚焦刀（ HIFU）治疗子宫肌瘤的有效性及安全性。方法运用HIFU对105例子宫肌瘤患者实施治疗，治疗后1个月、3个月、6个月随访观察患者的临床症状、肌瘤体积及不良反应，评估HFIU治疗的效果。结果治疗前子宫肌瘤体积为（48．1±17．8）cm3，治疗后1、3、6个月瘤体体积分别减小至（30．9±10．2）cm3、（24．5±8．6）cm3、（18．3±7．8）cm3，治疗前后差异均有统计学意义（t＝3．518、5.276、8．119，均P＜0．01）；HIFU治疗6个月后总体的有效率为80．9％，而对于肌层子宫肌瘤、直径小于5 cm的子宫肌瘤HIFU的有效率分别可达到为91．9％、93．8％。结论 HIFU治疗子宫肌瘤的近期疗效确切，且对于肌层及体积较小的肌瘤效率最为显著。

Objective To observe the efficacy and safety of high-intensity focused ultrasound （ HIFU ） therapy in uterine fibroids .Methods HIFU was used in the treatment process of 105 patients with uterine fibroids . Then ,we evaluated the treatment effect of HIFU through the follow-up observation of clinical symptoms ,fibroid volume and adverse reaction after treatment for 1 month,3 months,6 months.Results Before treatment,the tumor volume was （48.1 ±17.8）cm3,that was reduced to （30.9 ±10.2）cm3,（24.5 ±8.6）cm3,（18.3 ±7.8）cm3 at 1,3, 6 months after treatment,the differences were statistically significant （t =3.518,5.276,8,119,all P 〈0.01）. 6 months after treatment,the total effective rate was 80.9%.And for patients with muscular uterine fibroids ,uterine fibroids less than 5 cm,the effective rate was up to 91.9% and 93.8%,respectively.Conclusion HIFU has a positive impact on uterine fibroids ,especially for myometrium and smaller fibroids .