穴位注射鼠神经生长因子配合温针灸对糖尿病周围神经病变的影响

Rat Nerve Growth Factor with Warming Acupuncture Point Injection for Diabetic Peripheral Neuropathy

目的:观察鼠神经生长因子穴位注射配合温针灸治疗糖尿病周围神经病变(DPN)的疗效及安全性。方法:将40例糖尿病周围神经病变患者随机分为两组,对照组20例常规给予胰岛素或口服降糖药控制血糖及甲钴胺肌肉注射;治疗组20例在对照组治疗基础上加用温针灸配合鼠神经生长因子穴位注射。两组疗程均为30天。两组均在治疗前后采用可视化视觉模拟评分法(VAS)评定疗效、肌电图测腓总神经(common peroneal nerve)的MNCV及SNCV。结果:治疗组总有效率显著高于对照组(P<0.05),治疗组各项神经传导速度显著高于对照组(P<0.05)。结论:温针灸配合鼠神经生长因子足阳明经穴注射对糖尿病周围神经病变是一种比较安全有效的治疗方法。

Objective：To observe the efficacy and safety of nerve growth factor of rats by warm acupuncture and acupoint injection for the treatment of diabetic peripheral neuropathy （ DPN） .Methods：40 patients with diabetes peripheral neuropathy were randomly divided into two groups .20 cases in control group received normal insulin or oral medications to control blood sugar and muscle injection , a cobalt amine 1/d;Treatment group based on the therapy in the control group was given nerve growth factor with warm acupuncture point injection .The course was for 30 d.Visual analogue scale （ VAS） was to evaluate the curative effect and electromyography was to test MNCV and SNCV of common peroneal nerve .Results：The total effective rate in the treatment group was signifi-cantly higher than that in the control group （P〈0.05）, and in the treatment group the nerve conduction veloci-ty was significantly higher than that in the control group （ P〈0 .05 ） .Conclusion：Rat nerve growth factor with warming acupuncture point nerve injection for the treatment of diabetic peripheral neuropathy is safe and effec -tive.