新生儿窒息复苏后早期凝血功能变化与临床意义

The change of early stage coagulative function after recovery from stifle in newborn baby and its clinical significance

目的 探讨新生儿窒息复苏后早期凝血功能的变化特点及其临床意义.方法 对120例不同程度窒息复苏后新生儿（轻度窒息组81例、重度窒息组39例）治疗前后的血浆D-二聚体（DD）、蛋白C（PC）、血小板计数（PLT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）以及纤维蛋白原（Fg）水平的变化进行检测;另取同期出生的健康新生儿25例为对照组,对各组各项观察指标进行比较.结果 与对照组比较,窒息患儿的DD（t=17.65,P＜0.01）、PC（t=7.22,P＜0.01）、PLT（t重度=10.95,P＜0.01;t轻度=4.12,P＜0.01）、PT（t重度=13.01,P＜0.01;t轻度=8.09,P＜0.01）、APTT（t重度=12.70,P＜0.01;t轻度=8.53,P＜0.01）、TT（t重度=6.36,P＜0.01;t轻度=3.20,P ＜0.01）及Fg（t =21.24,P＜0.01）等指标均有明显变化,差异均有统计学意义,其中重度窒息组较轻度窒息组变化更大（均P ＜0.01）.结论 新生儿窒息后存在凝血功能紊乱,且凝血功能紊乱程度与窒息程度相关.

Objective To explore the change of early stage coagulation function of newborn baby recovery from stifle and its clinical significance.Methods 120 asphyxial neonates were selected randomly as research subjects.The DD,PC,PLT,PT,APTT,TT and Fg were detected and compared with normal newborn baby.Results The statistical analysis showed that DD （t =17.65,P ＜ 0.01）,PC （t =7.22,P ＜ 0.01）,PLT （tsevere =10.95,P ＜ 0.01 ;tmild=4.12,P＜0.01）,PT（tsevers =13.01,P＜0.01;tmild =8.09,P ＜0.01）,APTT（tsevers =12.70,P ＜0.01 ;tmild =8.53,P ＜ 0.01）,TT（tsevers =6.36,P ＜ 0.01 ; tmild =3.20,P ＜ 0.01） and Fg （t =21.24,P ＜ 0.01） of 120 patients had significant change,especially the severe stifle group had more significant change compared with mild stifle group.The treated babies relieved progressively and their indicators were back to normal.Conclusion There will be coagulation function disorder in early stage of newborn baby recovery from stifle.The degree of coagulation function disorder is related to the degree of stifle.