甲状腺结节内钙化灶的临床意义

The correlation between thyroid nodular and thyroid calcification

目的：探讨甲状腺结节钙化灶的临床意义。方法回顾性分析行手术治疗的430例甲状腺结节患者的彩色超声检查和病理检查资料。结果430例中，甲状腺癌49例（11．4％），其中微钙化灶30例（61．2％）和粗钙化灶3例（6．1％）；良性结节381例（88．6％），其中微钙化灶24例（6．3％）和粗钙化灶39例（10．2％）；两者差异有统计学意义（ P＝0．000）。甲状腺癌与钙化灶相关性分析：钙化类型：微钙化灶55.6％，粗钙化灶7．1％，P＝0．000；年龄：＜45岁48．8％，≥45岁22．6％，P＝0．007；结节数量：单个结节45．0％，多个结节16．7％，P＝0．005；甲状腺癌与性别无关（男性24．2％，女性39．7％，P＝0．130）。结论微钙化灶可以作为彩色超声检查诊断甲状腺癌的特异性指标。

Objective To explore the relation between thyroid nodular and thyroid calcification .Methods The clinical data of 430 cases with nodular goiter admitted from January 2011 to December 2013 were reviewed.All cases were performed ultrasonography and pathologic examination .Results Of 430 cases,there was thyroid carcinoma in 49 cases（11.4%）,including microcalcification in 30 cases（61.2%） and macrocalcification in 3 cases（6.1%）;benign lesion in 381 cases（88.6%）,including microcalcification in 24 cases（6.3%） and macrocalcification in 39 cases（10.2%）.The difference was remarkable （P=0.000）.There was remarkable difference in malignant calci-fied nodules ratio between the patients with microcalcification and macrocalcification （55.6%vs 7.1%,P=0.000）, between the patients aged 45 years below and above（48.8%vs 22.6%,P=0.007）,between the patients with solita-ry and multiple nodules（45.0%vs 16.7%,P=0.005）.But there was no statistic difference in malignant calcified nodules ratio between the male and female groups （24.2% vs.39.7%,P=0.130）.Conclusion Microcalcification is a highly specific sign to predict thyroid carcinoma in ultrasonography exam .Positive intervention will be performed immediately when calcification appears in thyroid nodules .