母亲知识影响苯丙酮尿症患儿血苯丙氨酸浓度

Effect of maternal knowledge on blood phenylalanine concentration in children with phenylketonuria

目的:探讨母亲知识水平与苯丙酮尿症(PKU)患儿血苯丙氨酸浓度控制的相关性。方法:收集139例PKU儿童(男孩74例,女孩65例),均在医生指导下接受低苯丙氨酸饮食治疗。16道有关PKU综合知识及其饮食治疗知识的问题提供给患儿的母亲,患儿3岁前的平均血苯丙氨酸浓度用作评估PKU控制效果的指标。结果:83个孩子平均血苯丙氨酸值高于推荐水平,母亲对PKU相关知识与患儿血苯丙氨酸水平呈负相关(P<0.05)。结论:母亲知识水平对PKU患儿预后有着重要影响。

Objective： To explore the correlation between maternal knowledge level and control of blood phenylalanine concentration in children with phenylketonuria （PKU） . Methods： A total of 139 children （74 boys and 65 girls） with PKU were collected and treated with dietary therapy with low phenylalanine under the guidance of a doctor; 16 problems about PKU comprehensive knowledge and dietary therapy were provided to their mothers, mean blood phenylalanine concentration before three years was used as evaluation index of PKU controlling effect. Results： The mean blood phenylalanine concentration of 83 children were higher than recommended level, there was a significantly negative correlation between maternal PKU knowledge and blood phenylalanine concentration of children （ P 〈 0.05 ） . Conclusion： Maternal PKU knowledge has important impact on prognosis of PKU children.