支气管肺炎伴血小板增多患儿临床特征及免疫状态的调查

Investigation on clinical characteristics and immune state of children with bronchial pneumonia combined with thrombocytosis

目的:探讨小儿支气管肺炎伴血小板增多的临床特征及炎症因子的变化情况。方法:根据血液检查结果将102例支气管肺炎患儿分为单纯支气管组78例(A组)以及支气管肺炎合并血小板增多组34例(B组),对比两组患儿临床特点、肺功能、免疫功能、炎症因子水平的差异。结果:与A组患儿相比,B组患儿年龄较小,喘息、呼吸困难症状较重,住院时间较长,并发症及死亡率较高(P<0.05)。A组IgA、IgG及CD3+水平较B组高,而CD19+CD23+、CD3-CD19+细胞比例、TNF-α、IL-6、CRP水平则低于B组(P<0.05)。结论:与单纯支气管肺炎患儿相比,支气管肺炎合并血小板增多患儿病情较重。外周血小板增多可作为肺炎支气管病情进展的预测指标,在小儿支气管肺炎临床诊断中具有一定的应用价值。

Objective： To explore the clinical characteristics and changes of inflammatory cytokines in children with bronchial pneumonia combined with thrombocytosis. Methods： A total of 102 children with bronchial pneumonia were divided into simple bronchial pneumonia group （78 children, group A） and bronchial pneumonia combined with thrombocytosis group （34 children, group B） based on blood test results. The clinical characteristics, pulmonary function, immune function and inflammatory cytokines levels in the two groups were compared. Results： Compared with group A, the children in group B was younger, wheezing and dyspnea were severer, the hospitalization time was longer, the incidence rate of complications and mortality rate were higher, there were statistically significant differences （P 〈 0. 05 ） . The levels of IgA, IgG and CD3 ^＋ in group A were statistically significantly higher than those in group B （P 〈 0.05） ; the proportions of CD19 ^＋ CD23 ^＋and CD3 ^- CD19 ^＋ , TNF - α, IL - 6 and CPR levels in group A were statistically significantly lower than ＇those in group B （P 〈 0. 05） . Conclusion： Compared with children with simple bronchial pneumonia, the children with bronchial pneumonia combined with thrombocytosis are more severer. Thrombocytosis in peripheral blood can be used as a predictor of aggravation of bronchial pneumonia, which has a certain application value in clinical diagnosis of bronchial pneumonia in children.