多囊卵巢综合征中医证型与糖代谢及IGF-I、IGFBP-1相关性的研究

Study on the Relationship between TCM Differentiation Types of Polycystic Ovary Syndrome and Glycometabolism,IGF-I and IGFBP-1

目的:拟探讨多囊卵巢综合征(PCOS)患者中医证型分布规律及与糖代谢、炎性因子IGF-I、IGFBP-1的关系。方法:对120例PCOS患者进行中医证候调查,同时检测患者BMI、胰岛素抵抗稳态模式评估及胰岛素生长因子-I(IGF-I)、胰岛素生长因子结合球蛋白-1(IGFBP-1)水平。并探讨中医证型与糖代谢异常、IGF-I、IGFBP-1的关系。结果:临床辨证分为肾虚、脾虚痰湿、肝郁气滞,构成比分别为35%,33%,32%。各证型间比较P>0.05,差异无统计学意义。脾虚痰湿组BMI、FINS、Homa-IR,P均<0.05,差异具有统计学意义,脾虚痰湿组IGFBP-I较肾虚、肝郁气滞组下降,P均<0.05,差异具有统计学意义,脾虚痰湿组IGF-I与肾虚、肝郁气滞组高比较升高,差异无统计学意义(P>0.05)。结论:PCOS中医证型以肾虚、脾虚痰湿、肝郁气滞为主,脾虚痰湿证与胰岛素抵抗、IGFBP-I下降有关。

To investigate the regularities of distribution of TCMdifferentiation types of polycystic ovary syndrome,and its re-lationship with glycometabolism and inflammatory factors IGF-I and IGFBP-1 .Methods：The TCM differentiation types of 1 20 cases of PCOS patients was investigated,and at the same time their BMI,homeostasis model assessment insulin resistance and insulin growth fac-tor-I（IGF-I）,insulinlikegrowthfactorbindingimmunoglobulin-1（IGFBP-1） ofpatientsweremeasured.Therelationshipbetween the TCM differentiation of polycystic ovary syndrome and glycometabolism,IGF-I and IGFBP-1 were explored.Results：TCM differenti-ation types included kidney deficiency,phlegm-dampness due to deficiency of the spleen,stagnation of liver qi,and the constituent ratio was 35%,33%,and 32%.The difference in all the three groups was not significant,P＆gt;0.05.The levels of BMI,FINS,Homa-IR of phlegm-dampness due to deficiency of the spleen were higher than those of the other two groups,and the differences remained significant,P〈0.05 .The level of IGFBP-I of phlegmdampness due to deficiency of the spleen was lower than that of the other two,and the differences remained significant,P〈0.05 .The level of IGF-I phlegm-dampness due to deficiency of the spleen was higher than that of the other two,and the difference was not significant,P〉0.05.Conclusion：The TCMdifferentiation types of polycystic ovary syndrome mainly included kidney deficiency,phlegm-dampness due to deficiency of the spleen,stagnation of liver qi.The syndrome of phlegmdampness due to spleen deficiency was relevant to insulin resistance and decline of IGFBP-1 .