针刺对第三腰椎横突综合征的止痛作用与镇痛机制探讨

Analgesic Effect of Acupuncture on the Third Lumbar Trans-verse Process Syndrome and Exploration of the Analgesic Mechanism

目的:观察针刺治疗第三腰椎横突综合征的止痛作用,并探讨其镇痛机制。方法:对40例第三腰椎横突综合征患者进行针刺治疗(穴取横突处阿是穴、肾俞、委中,3次/周,3周为1个研究周期);并于治疗前(第0周)、治疗后(第3周)、回访时(第5周)用视觉模拟评分法(Visual Analogue Scale,VAS)进行疼痛评分;并用酶联免疫吸附试验(Enzyme Linked Immunosorbent Assay,ELISA)法检测血清白细胞介素6(Interleukin-6,IL-6)、白细胞介素10(Interleukin-10,IL-10)的水平。结果:治疗后(第3周)时,VAS值下降(P<0.05),血清IL-6、IL-10水平上升(P<0.05);回访时(第5周)VAS值下降(P<0.05),血清IL-6、IL-10水平下降(P<0.05)。结论:针刺对第三腰椎横突综合征有很好的止痛作用,其镇痛机制很可能是促进细胞因子的代谢进程。

To observe the analgesic efficacy of acupuncture treatment on the third lumbar trans-verse process syndrome,and to explore the analgesic mechanism.Methods：Forty patients with the third lumbar trans-verse process syndrome were given acupuncture therapy in acupoints of ashi（on transverse）,Shenshu（BL-23）,Weizhong（BL-40）with 3sessions a week,3 weeks as a course.The pain （VAS）and the level of interleukin-6,interleukin-1 0 in the serum detected by ELISA after treatment （on the third week）and returned visit （on the fifth week）were recorded.Results：After 3 weeks of treatment,the score of VAS decreased （P〈0.05 ）,and the level of interleukin-6 and interleukin-1 0 in the serum were increased （P〈0.05 ）.In the return visit,the value of VAS decreased （P〈0.05）,and the level of interleukin-6,interleukin-1 0 in the serum were fallen （P〈0.05）.Conclusion：Acupuncture treatment on the third lumbar trans-verse process syndrome had a better analgesic effect,and its analgesic mechanism may be promoting the metabolism of cytokines.