摘要
目的探讨扎里奴思方治疗急性脑梗死的疗效及可能机制。方法将同期收治的84例急性脑梗死患者随机分为治疗组及对照组各42例,两组均予甘露醇、拜阿司匹林、丹参酮等常规治疗,在此基础上治疗组予扎里奴思方1付/d,14 d为一疗程,总共治疗两个疗程;对照组给予尼莫地平片30mg/次,1/d。治疗前后分别行神经功能评估并据此判定疗效,同时检测治疗前后血清神经元特异性烯醇化酶(NSE)水平改变。结果两组治疗7、14、28 d后进行比较,治疗组总有效率显著高于对照组(P<0.05);治疗后两组血清NSE水平均降低,尤以治疗14d组为显著(P均<0.01)。结论扎里奴思方治疗急性脑梗死可显著改善患者预后,其可能机制与下调NSE的表达、促进神经元功能的修复有关。
Objective To observe the effects and clinical effects of Zhali Nusi Fang on contents of NSE in the serum of patients with acuter cerebral infarction. Methods 84 patients were separated into the treatment group and the control group with a random- ized and controlled method. The control group received routine treatment of western medicine and the treatment group took Zhali Nusi Fang. ld days were one course of treatment, after two courses of treatment ,Neurological assessment and the levels of serum NSE in both groups were compared before and after treating. Results The treatment group was superior to the control group re- markably in clinical effects （P 〈 0.05 ） ; After treatment, the serum NSE were lower, especially in the treatment of 14d group was significantly （P 〈0.01 ）. Conclusion Zhali Nusi Fang can significantly improve the prognosis of patients with acute cerebral in- farction, and its possible mechanism is decreased expression of NSE and promote neuronal function repair.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2014年第7期1750-1751,共2页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金(No.81260569)
宁夏科技支撑计划(No.2012ZYH230)
