乙型肝炎病毒前C区(1896)和BCP区(1762/1764)变异对肝癌发病率的影响

Effects of Hepatitis B Virus Procore 1896 and Basal Core Promoter 1762/1764 Mutations on Incidence of Hepatocellular Carcinoma

目的探讨乙型肝炎病毒(HBV)前C区(1896)和BCP区(1762/1764)变异对肝癌发病率的影响。方法对520例HBV感染(慢性乙肝)患者进行HBV前C区(1896)和BCP区(1762/1764)变异检测,并观察其继发肝癌情况。结果 520例慢性乙肝患者HBV前C区(1896)变异肝癌发病率为8.3%,BCP区(1762/1764)变异肝癌发病率为30.0%,前C区(1896)和BCP区(1762/1764)同时变异肝癌发病率为10.9%,变异者合计肝癌发病率为22.9%;前C区(1896)和BCP区(1762/1764)均未发生变异(野生型)肝癌发病率为1.1%。变异者肝癌发病率显著高于未发生变异者(P<0.01)。结论 HBV前C区(1896)和BCP区(1762/1764)变异可能与肝癌的发病有关,应加强对此类患者HBV基因变异的检测。

Objective To investigate the effects of hepatitis B virus （HBV） procure （PC） 1896 and basal core promoter （BCP） 1762/1764 mutations on the incidence of hepatocellular carcinoma. Methods HBV PC 1896 and BCP 1762/1764 mutations were determined in 520 patients with HBV infection （chronic hepatitis B）. The secondary hepatocellular carcinoma was observed in all patients. Results The incidence of hepatocellular carcinoma was 8.3% in patients with PC 1896 mutation, 30.0% in patients with BCP 1762/1764 mutation, and 10.9% in patients with both PC 1896 and BCP 1762/1764 mutations. Compared with patients without PC 1896 and BCP 1762/1764 mutations, the incidence of hepatocellular carcinoma significantly increased in patients with PC 1896 and BCP 1762/1764 mutations （22.9%vs 1.1%, P〈0.01）. Conclusion HBV PC 1896 and BCP 1762/1764 mutations are correlated with the occurrence of hepatocellular carcinoma. Therefore, the detection of HBV gene mutations should be strengthened in patients with HBV infection.