骨髓增生异常综合征与贫血性疾病骨髓及血细胞形态学比较分析

Comparative analysis of bone marrow and blood cell morphology between myelodysplastic syndrome and other anemic disease

目的观察无或偶见原始细胞的骨髓增生异常综合征(MDS)(MDS-RA、MDS-RCMD、MDS-U)骨髓及外周血细胞形态学特点,并与其他贫血性疾病(巨幼红细胞性贫血、不发作型阵发性睡眠性血红蛋白尿)进行比较。方法抽取患者骨髓及外周血并制成涂片,行瑞氏染色后,油镜下观察分析各种细胞形态及特征。结果无或偶见原始细胞MDS的红系、粒系、巨核系病态细胞与其他贫血性疾病比较均有显著性差异(P<0.05)。结论外周血及骨髓细胞形态学检查是MDS的主要诊断方法,细胞形态学异常对于MDS与其他贫血性疾病的鉴别诊断具有重要价值,对临床治疗决策有指导意义。

objective To analysis the cellular morphological characteristics of bone marrow and peripheral blood in myelodysplastic syndrome（MDS-RA,MDS-RCMD,MDS-U） most of which had none blast cells or occasional blast cells, and to compare them with other anemic disease including megaloblastic anemia and atypical paroxysmal nocturnal hemoglubinuria （a-PNH）. Methods The bone marrow and peripheral blood were collected from the patients for preparing the smears with Wright staining to study the features of different kinds of cells using microscope oil immersion lens. Results There was statistically significant difference of morbid cells of erythrocyte, granulocyte and megakaryocytic series between MDS and other anemic disease （P〈0.05）. Conclusion The cell morphology of peripheral blood and bone marrow is the main diagnostic method of the MDS. The abnormality of cell morphology play an important role in differential diagnosis of MDS and other anemic disease and are helpful to the selection of the therapeutic regimen.