MDM2、PETN和P53在子宫内膜异位症中的表达及其相关性研究

Expression of MDM2, PETN and P53 in endometriosis and its correlation studies

目的探讨MDM2、PETN和P53在子宫内膜异位症中的诊断价值及其与预后的相关性。方法随机挑选符合子宫内膜异位症标准的患者60例作为实验组,另选门诊体检中正常的女性60例作为对照组,应用免疫组化SP法和原位杂交方法检测实验组和对照组MDM2、PETN和P53的阳性率。结果数据显示实验组组织标本中MDM2、PETN和P53阳性率的比例显著高于对照组(P<0.05),通过Sperman等级相关分析,结果显示子宫内膜异位症的发生与MDM2、PETN和P53的阳性率呈显著正相关(r=0.096、0.038、0.162)。结论 MDM2、PETN和P53三者在子宫内膜异位症的发生发展中发挥着重要作用,通过检测组织标本中MDM2、PETN和P53的含量判断患者的恢复情况具有重要的临床应用价值。

Objective To investigate the endometriosis diagnosis value and its correlation analysis of the role of prog- nosis by MDM2, PETN and P53. Methods Sixty endometriosis patients were randomly selected as the experimental group, 60 cases normal women by outpatient medieal were randomly selected as the control group, the MDM2, PETN and P53 positive rate of two groups detected by immunohistochemical SP and fluorescence in situ hybridization were compared. Results The MDM2, PETN and P53 positive rate of the experimental group using immunohistochemical SP were higher than that of the control group（P〈0.05）. Sperman rank correlation analysis showed that the onset of endome- trial booth and MDM2, PETN and positive rate of P53 had a significant positive correlation （r=0.096, 0.038, 0.162）. Conclusion MDM2, PETN and P53 plays an important rolein endometriosis development, the detection of MDM2, PETN and P53 in tissue samples found in the patient＇s recovery have an important clinical value.