期刊文献+

心房颤动患者血清亲环素A、基质金属蛋白酶-2的表达水平及临床意义 被引量:1

下载PDF
导出
摘要 目的:检测心房颤动患者血清中亲环素A(CyPA)和基质金属蛋白酶-2(MMP-2)、金属蛋白酶组织抑制因子-2(TIMP-2)在心房颤动中的临床意义。方法:选取窦性心律患者100例为对照组(非房颤组)。采用ELISA法检测各组患者血清中CyPA、MMP-2和TIMP-2水平,同时测量左心房前后径(LAD)。结果:观察组左心房前后径大于对照组(P<0.01),且与房颤持续时间密切相关。显示观察组患者血清中CyPA与MMP-2水平呈正相关,CyPA浓度与LAD呈正相关。结论:CyPA和MMP-2/TIMP-2的联合检测可能对判断心房颤动患者的病变程度及指导治疗具有一定作用。
出处 《黑龙江医药》 CAS 2014年第4期906-908,共3页 Heilongjiang Medicine journal
基金 安徽省自然科学基金 编号:10040606Q44
  • 相关文献

参考文献6

二级参考文献36

  • 1张万起,袁直,宓怀风,元云峰,何炳林,王亦农.Human cyclophilin 33 (hCyP33) in T-cell binds specifically to poly(A)^+RNA (mRNA)[J].Science China Chemistry,2002,45(3):275-281. 被引量:1
  • 2Spinale FG, Coker ML, Bond BR, et al. Myocardial matrix degradation and metalloproteinase activation in the failing heart : a potential therapeutic target. Cardilvasc Res, 2000, 46:225-238.
  • 3Saharinen J, Hyytiainen M, Taipale J, et al. Latent transforming growth factor-beta binding proteins ( LTBPs ) structural extracellular nmtrix proteins for targeting TGF-beta action. Cytokine Growth Factor Rev, 1999, 10 : 99-117.
  • 4Peterson JT, Li H, Dillon L, et al. Evolution of matrix metalloproteinase and tissue inhibitor expression during heart failure progression int infracted rat. Cardiovasc Res, 2000, 46:307-315.
  • 5Nagahiro N, Kazuhiro Y, Yasushi S, et al. Differential activation of matrix metalloproteinases in heart failure with and without ventricular dilatation. Cardiovasc Res, 2003, 57:766-774.
  • 6Ducharme A , Frantz S, Aikawa M, et al. Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J Clin Invest, 2000, 106:55-62.
  • 7Heymans S, Luttun A, Nuyens D, et al. Inhibition of plasminogen activators or matrix metallproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure . Nat Med, 1999, 5:1135-1142.
  • 8Borg TK, Burgess ML. Holding it all together: organization and function(s) of the extracellular matrix of the heart. Heart Failure,1993,8 : 230-238.
  • 9Li YY, Feldman AM, Sun Y, et al. Differential expression of tissue inhibitors of metalloproteinases in the failing human heart.Circulation, 1998, 98 : 1728-1734.
  • 10Roten L, Nemoto S, Simsic J, et al. Effects of gene diletion of the tissue inhibitor of the matrix metalloproteinase-type 1 ( TIMP-1 ) on left ventricular geometry and function in mice. J Mol Cell Cardiol,2000, 32:109-120.

共引文献61

同被引文献12

引证文献1

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部