射干合剂灌胃后大鼠尿及粪便中6种成分含量

Content of Six Compounds in Urine and Feces After Intragastric Administration of Shegan Heji in Rat

目的了解大鼠灌胃射干合剂后,指标成分在大鼠血清内吸收及其在大鼠尿、粪中24 h排泄情况。方法采用液相色谱-质谱联用技术测定化合物的含量,大鼠代谢笼技术。结果给予射干合剂后24 h指标成分基本从大鼠体内排泄完。结论麻黄碱在大鼠体内24 h基本排泄,黄酮类化合物在体内有互相转化的可能。服用射干合剂不会造成体内麻黄碱及黄酮类化合物的蓄积。

Objective To study absorption of shegan heji marker components in blood and their excretion in urine and feces of rats, after intragastric administration of shegan heji. Methods LC-MS/MS was used for determination of marker compounds. Rat metabolic cage technology was employed. Results Excretion of marker components were completed 24 hours after administration. Conclusion Ephedrine can be excreted from rats within 24 hours. The possibility of mutual transformation of flavonoids exists in the body. Taking shegan heji will not cause accumulation of ephedrine and flavonoids in the body.