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1,3偶极环加成合成芳基螺环化合物的研究

Synthesis of 1,3-Dipolar Cycloaddition Research Aryl Spiro Compounds
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摘要 螺环化合物是一类天然产物和药物中常见的杂环化合物,它们具有多种生物活性,在医学上其抗菌、抗病毒、消炎等生物活性非常显著,是国内外研究的一个热点。1,3偶极环加成反应是一个重要的有机合成反应,它的应用很广泛,在多种药物中间体的合成中起了至关重要的作用。本文以1,3偶极环加成和点击化学的方法进行了一系列的芳基螺环化合物的合成研究及表征。 Spiro compounds were a class of natural products and drugs in common heterocyclic compounds , which had a variety of biological activities in medicine antibacterial , antiviral , anti-inflammatory and other biological activity , now it was a hot research topic.1,3 -dipolar cycloaddition reaction was an important organic synthesis reaction , its application was very wide and played a crucial role in the synthesis of a variety of drug intermediates.1, 3 dipolar cycloaddition and click chemistry were used to synthesize a series of synthesis of aryl spiro compounds and their characterization.
作者 何红强 柴科杰 徐伟明
机构地区 新疆大学 杭州师范大学
出处 《广州化工》 CAS 2014年第14期97-100,共4页 GuangZhou Chemical Industry
关键词 螺环化合物 1 3偶极环加成 spiro compounds 1,3 dipolar cycloaddition
分类号 O626.1 [理学—有机化学]
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参考文献13

  • 1Takahashi K, Witkop B, Brosse A, Maleque M. A, Albuquerque E. X. Total Synthesis and Electrophysiological Properties of Natural ( - ) -Perhy - drohistri - onicotoxin, its Unnatural ( + ) - Antipode and their 2 - Depentyl Analogs[J]. Chim. Acta. , 1982, 65 : 252 - 256.
  • 2Srivastav N, Mittal A, Kumar A. J. Clean Synthesis and Antibacterial Activities of Spiro ( pyrimido ( 4, 5 - b ) quinoline - 5, 5' - pyrrolo (2, 3 - d) pyrimidine) - pentagon - es[J]. Chem. Commun., 1992, 42 : 493 - 498.
  • 3Longeon, A. , Guyot, M. , Vacelet, 1. Araptysilfins - I and - II: Biologically active dibromotyrosine derivatives from the sponge Psammaplysilla Arabica[ J ]. Experen - tia. , 1990, 46 : 548 - 552.
  • 4Kobayashi J, Tsuda M, Agemi K, Shigemiri H, Ishibashi M, Sasaki T, Mikami Y. Spirooxindoles: reaction of 2,6 -diaminopyrimidin- 4(3H) - one and satins[ J]. Tetrahedrnn, 1991,47 : 6617 - 6618.
  • 5James, D. M, Kunze, H. B, Faulkner, D. J. J. Nat. One - Pot, Three - Component Cycloaddition of Nonstabilized Azomethine Ylides to 13 - Nitrostyrene, a Highly Electron Deficient Dipolarophile [ J ]. Prod. , 1991, 54:1137-1141.
  • 6Fisher E, Hirshberg Y. J. Ultrafast studies of photochromic spiropyrans in solution [J]. J. Am. Chem. Soc. , 1952:4522 -4524.
  • 7魏荣宝,李洪波,梁娅.含氧,氮,硫杂原子的螺环大分子化合物的研究进展[J].化学学报,2007:124-127.
  • 8魏荣宝,刘洋,郭金晶,刘博,张大为.含芴、蒽螺环结构电致发光材料的研究进展[J].有机化学,2008,28(3):390-397. 被引量：9
  • 9Malkoch M, Schleicher K, Drockenmuller E, Hawker C. J, Russell T. P, Wu P, Fokin V. V. Structurally diverse dendritic libraries: a highly efficient functionalization approach using click chemistry [ J ]. Macromolecules,2005, 38(9) : 3663 -3678.
  • 10Rostovtsev, V. V, Green, L. G, Fokin, V. V, Sharpless, K. B. Inhibitors of HIV -1 Protease by Using In Situ Click Chemistry [ J]. Angew. Chem. Int. Ed., 2002, 41:2596-2599.

二级参考文献76

  • 1Carvalho, A.; Dogos, A.; Isolani, P. C. Polyhedron 2000, 19, 1707.
  • 2Jiang, W.-L.; Wang, J.; Ding, G.-Y. Chin. J. Lumin. 21106, 27, 561 (in Chinese).
  • 3Liu, Q.-L.; Cao, D.-R. Chin. Polym. Bull. 2006, 9, 69 (in Chinese).
  • 4Yan, J.-A.; Zhen, H.-Y.; Chen, Q.-L. Chin. J. Lumin. 2006, 27, 700 (in Chinese).
  • 5Liu, W.-J.; Chen, Y.-R.; Xong, G.-X. Chem. Ind. Eng. Prog. 2006, 25, 895 (in Chinese).
  • 6Ding, W.; Liu, C.-L.; Zhang, W.-C.; Hou, X. Modem Chem. Ind. 2006, 26, 23 (in Chinese).
  • 7Liu, Y.-F.; He, Y.; Liu, L.; Chen, W.; Li, Y.-G.; Zou, T.; Hu, H.-F.; Hua, J.-D.; Sang, W.-B.; Meng, Z.-Y.; Chen, J. Chin. Polym. Bull. 2006, 5, 79.
  • 8Liu, Q.-Y.; Zhang, Z.-F. Semicon China 2006, 3, 33 (in Chinese).
  • 9Zhong, Z.-Y.; Jiang, Y.-D.; Wang, T. Adv. Display 2005, (12), 39 (in Chinese).
  • 10Sun, Y.-Y.; Hua, Y.-L.; Xu, F.; Yin, S.-G. J. Optoelectron. Laser 2005, 16, 1021 (in Chinese).

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广州化工
2014年 第14期

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