不同妊娠方式流产胚胎染色体异常发病率的调查

Compared the rate of chromosomal abnormalities in miscarriages after the different type of conception

目的调查不同妊娠方式对胚胎染色体异常的发病率的影响。方法选择在同时期因自然流产而进行绒毛染色体检查患者标本42例,自然妊娠流产胚胎19例,染色体异常发病率(8/19)42.1%;辅助生殖技术治疗后流产23例,染色体异常发病率(12/23)52.1%。比较自然妊娠和辅助生殖技术治疗后流产绒毛染色体异常比率。结果经统计学处理,自然妊娠和辅助生殖技术治疗后流产绒毛染色体异常比率无显著差异。结论胚胎染色体非整倍体是造成自然流产的重要原因,不同妊娠方式流产胚胎染色体非整倍体发生率经统计学分析无显著差异。

Objective： To evaluated the rate of chromosomal abnormalities in miscarriages after natural conceptions （NC） and assisted reproductive treatment （ART） .Methods： Cytogenetic analysis on spontaneous metaphases, obtained using direct method, was successfully performed on a total of 42 cases： 23 from patients who underwent assisted reproductive treatment （ART） and 19 samples from natural conceptions （NC） . An abnormal karyotype was observed in 12 （52.1%） cases after ART and in 8 （42.1%） after NC. Result： The study demonstrating that the ART group doesn＇t seem subjected to a higher cytogenetic risk due to the application of technical procedures. Conclusion： A large proportion of these spontaneous miscarriages are a result of chromosomal abnormalities, There is no increased risk of chromosomal abnormalities due to ART.