通塞脉片联合依帕司他治疗糖尿病周围神经病变的疗效

Clinical effect of Tongsaimai tablets and epalrestat on diabetic peripheral neuropathy

目的观察通塞脉片联合依帕司他治疗糖尿病周围神经病变的疗效。方法将62例糖尿病周围神经病变患者随机分为治疗组和对照组(各31例),在常规糖尿病综合治疗的基础上对照组给予依帕司他片,治疗组在依帕司他片基础上加服通塞脉片。两组疗程均为8周,治疗结束后比较两组患者的神经传导情况及临床效果。结果经过8周治疗,治疗组总有效率(87.10%)明显高于对照组(58.06%),差异有统计学意义(P<0.05),治疗组神经传导速度改善情况明显优于对照组(P<0.05)。结论通塞脉片联合依帕司他治疗糖尿病周围神经病变的临床疗效显著,好于依帕司他单独用药。

Objective To observe the clinical effect of Tongsaimai tablets combined with epalrestat on diabetic neuropathy. Methods Sixty -two patients with diabetic peripheral neuropathy were chosen and randomly divided into the treatment group and the control group, and each group consisted of 31 cases. The control group was given epalrestat,while the treatment group received additional services with Tong- saimai tablets on the basis of control group. The treatment duration was 8 weeks. After treatment,the clinical effect and nerve conduction veloc- ity of the two methods were observed. Results The total effective rate of treatment group was 87.10% ,which was 58.06% in control group （P 〈 0.05）. The improvement of nerves conduction velocity in treatment group was significantly pronounced than in controls （P 〈 0.05）. Conclusion Tongsaimai tablets plus epalrestat was art effective treatment approach for the management of diabetic peripheral neuropathy, which is superior to that of single epalrestat therapy.