低声压级水平次声波对未孕大鼠卵巢及孕鼠胚胎和仔鼠的影响

Effects of low-decibel infrasound on the ovary of non-pregnancy female rats,embryos and neonatal rats

目的：研究低声压级水平次声波（2～25 Hz/70 dB）对未孕大鼠卵巢结构和分泌功能的影响，同时探讨其对孕鼠的胚胎和仔鼠的影响．方法：将40只雌性大鼠随机分组：对照组A1与次声组A2各8只，处理后观察卵巢结构并测定血清中的雌二醇、睾酮、黄体生成素（LH）和卵泡刺激素（FSH）；其余雌鼠合笼，将孕鼠分为对照组B1与次声组B2、B3各6只，妊娠第6、12、18 d测血清中的雌三醇和孕酮；孕鼠分娩后记录仔鼠情况．结果：A 1和A2组及B 1、B2和B3组性激素水平均无统计学意义，A 1和A2组卵泡的数量及形态无明显差别，但A2组髓质层血管明显扩张．与B1组比较，B2、B3组仔鼠的体质量明显增加（P＜0.05）．结论：低声压级水平次声波可以增加卵巢的血液供应，但对卵泡的发育、卵巢的内分泌功能无明显影响；可增加仔鼠的体质量，但对胚胎无明显影响，低声压级水平次声波应用于孕妇是安全的．

Aim：To investigate the effects of low-decibel infrasound（2~25 Hz/70 dB）on the ovarian structure and the endocrine function of non-pregnancy female rats,and meanwhile to explore its influence on embryos and neonatal rats.Methods：Forty female rats were used,of which 16 were randomly divided into 2 groups with 8 in each：the control group A1 ,and the infrasound group A2.Then serum hormones were determined and the structure of ovary tissue was examined.The other female rats were mated.18 pregnant rats were equally divided into 3 groups：the blank group B1 and the infrasound groups,B2, B3.The serum estradiol and progesterone were determined at post-pregnant day 6,12,and 18,respec-tively.The neonatal rats were examined soon after delivery.Results：All of the serum hormone levels tested showed no statistically significant difference in this study.There were many different follicles ob-served,but no evident difference in quantity and morphology was found.However,blood vessels were found obviously dilated in the group A2.Compared to B1 ,the neonatal rat weights of B2 and B3 were found significantly increased （P＆lt;0.05 ）.Conclusion：Low-decibel infrasound may cause weight gain of＆amp;nbsp;neonatal rats and increase ovarian blood supply,without evident influence on embryo development,ovari-an structure and the endocrine functions.