急性心肌梗死患者心型脂肪酸结合蛋白与早期心功能的相关性

The relationship between serum H-FABP level and left ventricular dysfunction parameters in the patients with early AMI

目的:研究急性心肌梗死(AMI)患者血清心型脂肪酸结合蛋白(H-FABP)与早期心功能的相关性.方法:收集AMI患者209例及对照组98例;入院后6h内测定血清H-FABP,按照心功能Killip(Ⅰ-Ⅳ)分级、左室射血分数(LVEF)、左室舒张末期内径(LVEDd)及E/A比值进行分组,对比各组间血清H-FABP的差异;分析血清H-FABP与心功能参数的相关性.结果:AMI患者血清H-FABP随心功能Killip分级增加而显著升高(P<0.05);随LVEF水平降低,血清H-FABP水平均逐渐升高(P<0.05);随着LVEDd的增加,血清H-FABP逐渐升高(P<0.05);E/A比值≤1组血清H-FABP水平高于E/A比值>1组(P<0.05);血清H-FABP水平与LVEF、E/A比值呈负相关(r分别为-0.563,-0.497,P<0.05);与LVEDd呈正相关(r=0.519,P<0.05).结论:AMI患者血清H-FABP水平随Killip(Ⅰ-Ⅳ)分级增加逐渐升高;血清H-FABP与AMI早期LVEDd呈正相关,与LVEF、E/A比值呈负相关,血清H-FABP水平与AMI早期心功能参数具有相关性,对于AMI早期心功能评估具有重要价值.

Aim：To study the correlation between serum H-FABP level and left ventricular dysfunction parameters in patients with early AMI.Methods：Serum H-FABP level was determined within 6 hour in hospital in 209 patients with AMI and 98 healthy controls.Patients with AMI were grouped according Kil-lip grades（Ⅰ-Ⅳ）,LVEF,LVEDd and E/A ratio.Results：Serum H-FABP increased significantly in proportion with increasing Killip grades（Ⅰ-Ⅳ）（P＆lt;0.05 ）,and decreasing LVEF and E/A ratio （P＆lt;0.05 ）.Serum H-FABP positively correlated with LVEDd （P ＆lt;0.05 ）and negatively correlated with LVEF and E/A ratio （P＆lt;0.05 ）.Conclusion：Serum H-FABP level is positively correlated with Killip grades and LVEDd,negatively correlated with LVEF and E/A ratio.H-FABP has diagnostic value of heart failure in early AMI.