CD45RA、CD45RO及胞间黏附分子1在扁平苔藓皮损中的表达

Expression of CD45RA, CD45RO and ICAM-1 in the lesions of patients with lichen planus

目的探讨扁平苔藓(LP)皮损CD45RA、CD45RO及胞间黏附分子1(ICAM-1)的表达及意义。方法应用免疫组化方法检测35例LP皮损和20例正常皮肤组织中CD45RA、CD45RO及ICAM-1的表达水平。结果 LP皮损真皮内可见到CD45RO阳性表达,与正常对照组有统计学差异(P<0.05);LP皮损表皮、真皮及真皮内小血管壁内皮细胞内均可见ICAM-1阳性表达,与正常对照组有统计学差异(均P<0.05);两组均未见CD45RA阳性细胞表达。结论 LP皮损真皮内浸润细胞以记忆T细胞亚群为主,LP皮损角质形成细胞异常表达ICAM-1,推测ICAM-1参与了皮损角质形成细胞抗原呈递过程,从而促进记忆T细胞离开血管,向真皮及表皮浸润。

Objective To investigate the expression of CD45RA, CD45RO and ICAM-1 in the lesions of patients with lichen planus. Methods The expression levels of CD45RA and CD45RO and ICAM-I were detected in 35 cases of LP lesion tissue and 20 cases of normal skin tissue by using immunohistochemical methods. Results CD45RO positive expression can be seen in the dermis of LP lesions, and had statistical difference compared with normal control group （P〈0.05）; the positive expression of ICA_M-1 were visible within LP skin epidermis, dermis and small blood ＂vessels endothelial cells in the dermis, and had statistical difference compared with the normal control group （all P〈0.05）; CD45RA positive cells expression were not found in both groups. Conclusion The dermal infiltrating ceils are mainly memory T cells subset in the lesions of lichen planus, the significant expression of ICAM-1 in keratinocytes of LP patients suggest that ICAM-1 take part in the progress of the antigen-submit of keratinocytes, and promote the inflammatory cells infiltrating to epidermis.