高血压患者血清高敏C反应蛋白与血压分级的关系研究

Relationship between high-sensitivity C-reactive protein and blood pressure grading in hypertensive patients

目的探讨血清高敏C反应蛋白水平与中老年人高血压分级的关系。方法选取2013年6月至2013年11月于北京市安贞医院体检的209例中老年人为研究对象,根据中国高血压防治指南2010的诊断标准分为对照组(n=105)和高血压组(n=104),后者再根据高血压程度分为高血压病1、2、3级3个亚组,所有受试者均检测血清高敏C反应蛋白(hs-CRP)水平。结果对照组患者血浆hs-CRP水平为(1.57±2.18)mg/L,高血压组患者hs-CRP水平为(3.91±4.64)mg/L,两组比较差异具有统计学意义(P<0.05)。与高血压病1级hs-CRP水平[(2.95±3.27)mg/L]比较,高血压病2级hs-CRP水平[(5.73±4.00)mg/L]增高,但差异无统计学意义(P>0.05);而高血压病3级hs-CRP水平[(7.60±8.13)mg/L]明显升高,差异有统计学意义(P<0.05)。高血压病3级较高血压病2级hs-CRP水平明显升高(P<0.05)。结论高血压患者血清hs-CRP水平增高,高血压分级越高,血清hs-CRP水平增高越显著。

Objective To investigate the relationship between the level of serum high-sensitivity C-reactive protein （hs-CRP） and blood pressure grading in elderly hypertensive patients. Methods The elderly patients （n=209） were chosen from Beijing Anzhen Hospital from Jun. 2013 to Nov. 2013 as study subjects. According to the diagnostic standard in the Chinese Hypertension Prevention and Cure Guideline （2010）, the patients were divided into control group （n=105） and hypertension group （n=104）, and hypertension group was divided further into 3 subgroups （grade I subgroup, grade II subgroup and grade III subgroup） according to hypertension grading. The level of serum hs-CRP was detected in all groups. Results The level of serum hs-CRP was （1.57±2.18） mg/L in control group and （3.91±4.64） mg/L in hypertension group （P〈0.05）. The level of serum hs-CRP increased in grade II subgroup [（5.73±4.00） mg/L] compared with grade I subgroup [（2.95±3.27） mg/L] but the difference had no statistical significance （P〉0.05）, and increased significantly in grade III subgroup [（7.60±8.13） mg/L] （P〈0.05）. The level of serum hs-CRP increased significantly in grade III subgroup compared with grade II subgroup （P〈0.05）. Conclusion The level of serum hs-CRP will increase in hypertensive patients, and the higher the hypertension grading, the more significant the increase of hs-CRP level.