慢性阻塞性肺病急性加重期合并焦虑抑郁的临床分析

The clinical analysis of acute exacerbation of chronic obstructive pulmonary disease combined with pulmonary embolism

目的:了解慢性阻塞性肺病急性加重期(AECOPD)患者合并焦虑抑郁的情况,并探讨其可能的影响因素。方法:用汉密尔顿焦虑、抑郁量表判断患者是否存在焦虑抑郁症状,观察焦虑抑郁与相关临床资料、肺功能等的相关性。结果:45例患者中合并焦虑和/或抑郁者21例(46.7%),无焦虑抑郁24例(53.3%)。COPD合并焦虑抑郁组临床COPD问卷(CCQ)评分、前1年急性加重次数高于无焦虑抑郁组(P<0.05);FEV1%、FEV1/FVC低于无焦虑抑郁组(P<0.05)。结论:AECOPD患者易合并焦虑抑郁障碍,病程、前1年急性加重次数、CCQ评分及肺功能可能是其主要影响因素。

Objective. To investigate the prevalence of anxiety and depression in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods： The Hamilton anxiety and depression scale were used to determine whether the patients were with anxiety and depression. The correlated clinical data of anxiety and depression, and pulmonary function in patients were observed. Results： Of the 45 patients, 21 cases were with anxiety and/or depression（46.7%）, 24 cases were without anxiety and depression（53.3%）. Compared with the COPD group without anxiety and depression, clinical COPD questionnaire（CCQ） score, frequency of acute exacerbation one year before, and course of disease in the COPD group combined with depression and anxiety were lower （P〈0.05）. FEV1% and FEV1/FVC were higher in group with depression and anxiety（P〈0.05）. Conclusion. The patients with AECOPD were easily combined with anxiety and depression. The course of disease, frequency of acute exacerbation one year before, CCQ score and pulmonary function may be the primary influential factors.