药物在中心室平均滞留时间的计算方法

An Algorithmic Method for Mean Residence Time in Central Compartment

目的提供一种药物在中心室平均滞留时间(mean residence time in central compartment,MRTc)的计算方法。方法将药物浓度-时间曲线转换为药物分子数量-时间曲线,对此曲线下面积进行积分,得药物分子在中心室滞留的总时间,除以药物分子总数可得中心室平均滞留时间。通过对仿真数据中心室平均滞留时间的计算,对算法进行评价。结果最终的算法为MRTc=(AUC·V)/(F·Dose),该算法对血管内、外给药的线性和非线性动力学数据均有可靠的计算结果。结论 (AUC·Vc/F·Dose)可用于计算药物的中心室平均滞留时间,与药物在整个机体的平均滞留时间(mean residence time,MRT)的计算方法,MRT=(AUMC/AUC)配合使用有助于更好的阐述药物的体内行为。

OBJECTIVE To provide a method for calculating mean residence time of drugs in central compartment （ MRTc ）. METHODS The drug concentration-time curve was transformed to drug molecular number - time curve, which could be integrated to get the total residence time of drug molecule in the central compartment. The total residence time divided by the molecular number was equal to MRTc. This algorithm was estimated through analyzing the simulation data. RESULTS MRTc = （AUC · Vc/F · Dose） The algorithmic method was, and it could get accurate result for linear and nonlinear pharmacokinetics of intravenous and extra-vascular administration. CONCLUSION The method put forward in this study can be used to calculate MRTc. The combination of this method with the algorithmic method of mean residence time （MRT） in entire body MRT = AUMC/AUC can provide a better understanding of the in vivo behavior of drugs.