唐山地区3家医院脑梗死二级预防中叶酸的应用现况调查

Survey on the Application of Folic Acid in Second-grade Prevention of Cerebral Infarction in 3 Hospitals from Tangshan Area

目的:了解唐山市部分医院脑梗死二级预防中叶酸的应用现状,找到与相关指南之间的差距,为改进脑梗死二级预防工作提供参考。方法:研究对象为唐山市3家医院诊断为脑梗死的住院患者共573例,按照血浆总同型半胱氨酸(tHcy)水平将入选病例分为3组,调查不同组别患者二级预防中叶酸的应用现状。结果:叶酸的使用率在血浆tHcy重度升高组为62.9%,在中度升高组中为50.7%,在轻度升高组中为38.1%,3组间比较差异有统计学意义(P<0.05);但叶酸的使用量3组间比较差异无统计学意义(P>0.05)。结论:唐山地区部分医院对叶酸应用于脑梗死二级预防已经有了一定程度的认识,但使用率、使用量等与相关指南尚有距离,需进一步加强对医务人员的培训。

OBJECTIVE： To understand the application of folic acid in second-grade prevention of cerebral infarction in some hospitals from Tangshan, and to find out the gap of it with guidance and provide reference for the improvement of second-grade pre- vention of cerebral infarction. METHODS ： 573 patients diagnosed as cerebral infarction in 3 hospital from Tangshan were chosen as the subjects. According to the tHcy level, the subjects were divided into 3 groups to investigate the application of folic acid in sec- ond-grade prevention in patients in different groups. RESULTS： The application rates of folic acid were 62.9 % in the group in which plasma homocysteine significantly elevated, 50.7% in moderately elevated group and 38.1% in slightly elevated group; there were statistical significance （P〈0.05）; but the use of folic acid among the 3 groups showed no statistical difference （P〉0.05）. CONCLUSIONS ： The physicians in neurology department of some hospitals from Tangshan area has a certain degree of knowledge about the amount of folic acid in the second-grade prevention for cerebral infarction, but there still are the distance of it with guidance such as folic acid rate and amount, so further staff training should be strengthened.