摘要
[目的]采用家兔耳缘静脉注射法考察尼莫地平缓释制剂对家兔血管刺激性试验。[方法]将家兔分为阴性对照组(生理盐水组)、尼莫地平注射液组和尼莫地平缓释制剂组,分别通过耳缘静脉注射,给药剂量为0.5 mg/kg。[结果]生理盐水组和尼莫地平缓释制剂组没有出现明显的血管刺激现象,而尼莫地平注射液组出现强烈的血管刺激现象。[结论]尼莫地平缓释制剂与原制剂尼莫地平注射液相比,有效降低了家兔血管刺激性,为其临床上广泛应用提供了一定基础。
[ Objective ] To study the vascular stimulation test of Nimpdipine sustained release preparations for rabbits by ear marginal vein in- jection. [ Method] Making the rabbit to Nacl model group, Nimpdipine injection group and Nimpdipine sustained release preparations group, each by ear marginal vein injection, the dose was 0.5 mg/kg. [ Result] The Nacl group and Nimpdipine sustained release preparations group has no obvious vascular stimulation, but the vascular stimulation of Nimpdipine injection group is very obvious. [ Conclusion] Nimpdipine sus- tained release preparations effectively reduce the Vascular stimulation, and it is suitable for widely used cilinically.
出处
《安徽农业科学》
CAS
2014年第23期7781-7781,7796,共2页
Journal of Anhui Agricultural Sciences
关键词
尼莫地平缓释制剂
血管刺激性
家兔
Nimpdipine sustained release preparations
Vascular stimulation test
Rabbit
