PCT、CRP在慢性阻塞性肺疾病合并肺炎患者中的意义

Significance of serum procalcitonin and C-reactive protein in patients with chronic obstructive pulmonary disease combined with pneumonia

目的:观察血清降钙素原(PCT)、C反应蛋白(CRP)水平对判断慢性阻塞性肺疾病(COPD)患者合并肺炎及其严重程度的意义。方法:将158例COPD患者根据入院病情分为非感染组77例、普通肺炎组58例、重症肺炎组23例,于入院后24h内进行CRP、PCT检测并进行分析比较。结果:非肺炎组、普通肺炎组及重症肺炎组患者血清PCT、CRP水平差异有显著性(P<0.01),普通肺炎组及重症肺炎组患者PCT与CRP曲线下面积比较有统计学意义(P<0.05)。结论:PCT、CRP对评判COPD患者是否合并肺炎及肺炎严重程度有临床指导意义,其中PCT的指导意义更大。

ObjectiveTo evaluate significance of serum procalcitonin （PCT） and C-reactive protein （CRP） levels in patientswith chronic obstructive pulmonary disease combined with pneumonia. Methods：158 patients with chronic obstructive pulmonary dis-ease were divided into three groups： non-pneumonia group （77 patients）, common pneumonia group （58 patients） and severe pneu-monia group （23 patients）. The serum CRP and PCT levels were determined in the first 24 hours of admission and compared. Results：The PCT and CRP levels in severe pneumonia group were significantly higher than those of non-pneumonia group and common pneumo-nia group （P〈0. 01）. The PCT and CRP levels in common pneumonia group were significantly higher than those in non-pneumoniagroup （P〈0. 01）. The area under the curve of PCT was larger than that of CRP （P〈0. 05）. Conclusions： The serum PCT and CRPlevels are valuable in the patients with chronic obstructive pulmonary disease combined with pneumonia, and the PCT level is more im-portent than CRP.