硫酸镁治疗早产的使用强度对妊娠结局的影响

THE INFLUENCE OF THE INTENSITY OF MAGNESIUM SULFATE IN THE TREATMENT OF PREMATURE DELIVERY ON PREGNANCY OUTCOME

目的评价硫酸镁治疗早产的用药频度(Defined daily dose system,DDDs)和使用强度(Tocolytics use density,AUD)对妊娠结局的影响,指导硫酸镁的临床合理应用。方法计算2009年1月—2013年12月于该院接受硫酸镁安胎治疗患者的硫酸镁DDDs和AUD,收集患者妊娠结局数据,评价硫酸镁DDDs和AUD与妊娠结局的关系。结果宫缩欠佳组与宫缩好组、孕37周前分娩组与孕37周后分娩组、不良出生结局组与良好出生结局组相比,其硫酸镁DDDs和AUD均差异有统计学意义(P<0.05)。结论硫酸镁的使用强度与子宫收缩能力、新生儿出生结局存在关系,临床应注意硫酸镁的合理应用,避免大剂量和连续使用。

Objective To evaluate the influence of the DDDs and AUD of magnesium sulfate in the treat- ment of premature delivery on the pregnancy outcome, and then to guide the clinical rational use of magnesium sulfate. Methods The DDDs and AUD of magnesium sulfate and the data of pregnancy outcome of all the patients with preterm birth who were enrolled in author＇s hospital from 2009 to 2013 were summarized, and the relationship between DDDs and AUD of magnesium sulfate and pregnanee outcome was evaluated. Results The DDDs and AUD of magnesium sulfate had significant difference between the groups of uterine inertia and well uterine contraction, the groups of preterm birth ≥37 weeks＂ gestation and 〈37 weeks＂ gestation, and the groups of good neonatal outcome and bad neonatal outcome, respectively. Conclusions The high AUD of magnesium sulfate can affect the uterine contraction and neonatal outcome. To promote the clinical rational drug use of magnesium sulfate is in urgent need.