急性髓系白血病患者CXXC5基因表达水平及与预后的相关性

Correlation between the expression levels of CXXC5 gene and prognosis of patients with acute myeloid leukemia

目的研究急性髓系白血病(AML)患者中CXXC5基因的表达水平,并分析其与临床病理特征的相关性。方法应用EvaGreen实时定量PCR(RQ-PCR)方法检测AML患者中CXXC5基因表达量。结果结果显示与24例对照相比,94例AML患者CXXC5转录本水平显著降低(P<0.01)。44例(45.8%)AML患者为CXXC5基因低表达,M1/M2/M3亚型患者CXXC5基因的低表达率显著高于M4/M5/M6亚型(P<0.01)。CXXC5基因低表达的AML患者总体生存时间(OS)显著长于非低表达者(P<0.01)。结论 CXXC5低表达常见于AML患者中,且对AML预后具有良性影响。

Objective To investigate the expression levels of CXXC5 gene in patients with acute myeloid leukemia（ AML）,and to explore its correlation with clinical pathological characteristics. Methods The expression levels of CXXC5 in96 patients with AML（ AML group） and 19 cases of iron deficiency anemia as well as 5 cases of immune thrombocytopenia（ control group） were detected by RQ-PCR. Results The expression levels of CXXC5 gene in AML group were significantly decreased,as compared with those in control group（ P〈0. 01）. The low-expression of CXXC5 gene was found in 44 cases of AML（ 45. 8%）. The low-expression rate（ 86. 4%） in AML patients with M1 /M2 /M3 subtype was significantly higher than that of AML patients with M4 /M5 /M6 subtype（ 13. 6%,P〈0. 01）. The overall survival（ OS） time in AML patients with low-expression of CXXC5 was obviously longer than that of AML patients with non low-expression of CXXC5（ P〈0. 01）.Conclusion The low-expression of CXXC5 is a common and favorable event in patients with AML,which is favorable to prognosis of AML patients.