右美托咪啶减轻小儿全麻诱导期舒芬太尼呛咳反应的临床观察

Dexmedetomidine Reducing Sufentanil Induced Cough during Children General Anesthesia Induction

目的:评价右美托咪啶减轻小儿全麻诱导期舒芬太尼诱发呛咳反应的临床有效性。方法:选择2011年5月-2013年11月在笔者所在医院行择期手术患儿60例,将其随机分为对照组与试验组,每组30例,麻醉前15 min试验组静脉恒速泵注右美托咪啶,对照组静脉恒速泵注生理盐水,泵注15 min。泵注结束后两组患儿均静脉注射丙泊酚2 mg/kg与舒芬太尼0.5μg/kg和维库溴铵0.1 mg/kg麻醉诱导,术中以丙泊酚和瑞芬太尼维持麻醉。观察静脉注射舒芬太尼后5 min内呛咳反应发生率和程度以及血流动力学的变化。结果:两组血流动力学变化没有显著性差异,试验组呛咳发生率和程度均显著低于对照组(P<0.05)。结论:右美托咪啶可有效抑制全身麻醉诱导期舒芬太尼引发的呛咳反应。

Objective： To observe the effects of Dexmedetomidine in reducing children cough induced by Sufentanil in general anesthesia induction. Method： Our hospital from May 2011 to November 2013, 60 children undergoing elective operation, the pediatric patients were randomly divided into control group and experimental group, 30 cases in each group.15 min before experimental group constant rate intravenous infusion of Dexmedetomidine, the control group constant rate intravenous infusion of saline infusion pump, 15 min.Pump after the end of the two groups were intravenous injection of Propofol 2 mg/kg with Sufentanil 0.5 μg/kg and Vecuronium 0.1 mg/kg anesthesia induction.During the maintenance of anesthesia with Propofol and Remifentanil.Observation of intravenous Sufentanil post to 5 rain cough frequency and hemodynamic changes.Result： The hemodynamic changes of two groups were compared, there were no significant differences, but the rate and degree of cough in the experimental group were significantly better than the control group（P〈0.05）.Conclusion： The induction period of Sufentanil induced cough suppression of Dexmedetomidine can effectively general, anesthesia.