前降钙素与CRP测定在新生儿败血症诊疗中的价值

Value of Procalcitonin and CRP in the Diagnosis and Treatment of Neonatal Sepsis

目的:探讨前降钙素(PCT)、C反应蛋白(CRP)测定在新生儿败血症诊断疗效评价中的价值。方法:选择60例新生儿败血症患儿为观察组,选择60同期在笔者所在医院产科分娩的足月健康新生儿为对照组,分别对两组新生儿测定血清PCT及CRP含量并比较,观察组治疗1周后检测血清PCT及CRP含量,比较治疗前后血清PCT及CRP含量的变化。结果:观察组新生儿PCT(8.01±4.02)ng/L、CRP(23.16±3.78)mg/L显著高于对照组(P<0.01);观察组治疗1周后PCT(1.90±0.25)ng/L、CRP(4.08±1.09)mg/L显著低于治疗前(P<0.01)。结论:新生儿败血症前降钙素及C反应蛋白含量均显著升高,治疗后显著降低,两者测定有助于新生儿败血症的确诊及疗效评价。

Objective：To investigate the value of procalcitonin（PCT）,C -reactive protein （CRP） in the diagnosis and treatment of neonatal sepsis. Method：60 cases of neonatal sepsis were as observation group,60 full-term healthy newborns at the same period in our hospital were choosed as control group, respectively,neonatal serum PCT and CRP level was detected and compared in the two groups,and after treating one week in the observation group,serum PCT and CRP level was detected,serum level of PCT and CRP was compared before and after treatment.Result：The level of PCT was （8.01±4.02）ng/L,the level of CRP was （23.16±3.78）mg/L,they were significantly higher in the observation group than those in the control group（P〈0.01）.After treating one week in the observation group,the level of PCT was （1.90±0.25）ng/L,the level of CRP was （4.08±1.09）mg/L,they were significantly lower than before treatment（P〈0.01）. Conclusion：The level of procalcitonin and C-reactive protein in neonatal sepsis are significantly increased,and decreased significantly after treatment,they can contribute to diagnosis and treatment evaluation of neonatal sepsis .