摘要
清蛋白(白蛋白)是一种理想的药物载体,但由于其在体内半衰期短以及易被酶降解等缺点限制了其应用,然而根据其具有多个修饰位点的结构特点,可通过PEG修饰延长循环时间,阻碍酶的作用等。目前,PEG修饰清蛋白仍处于研究阶段,已有较多关于PEG修饰清蛋白的研究,例如PEG修饰所起的作用、对清蛋白及其制剂的影响,以及修饰位点的选择等。本文对清蛋白的PEG化修饰的相关研究进行综述。
Albumin is an ideal drug carrier,but its application was limited because of the shortcomings of short half-life and susceptible to enzymatic degradation in vivo.However,according to its structural features,albumin has a plurality of modification sites,which can be modified by PEG modifier to extend the cycle time and obstruct the action of the enzyme.Currently,the PEG-modified albumin is still in the research stage,and there have been many studies about PEG-modified albumin,such as the role of PEG modification,the effects on albumin and its preparations and the modification sites selection.The article reviewed the related studies about the PEGylation of albumin.
出处
《药学实践杂志》
CAS
2014年第4期241-245,265,共6页
Journal of Pharmaceutical Practice
关键词
清蛋白
PEG化
半衰期
药剂学性质
修饰位点
albumin
PEGylation
half-life
pharmaceutical characterization
modification sites