两亲性环三磷腈的制备、自组装及应用

Preparation and Application of Self-assembly of Amphiphilic Cyclotriphosphazene

合成了一种新的两亲性环三磷腈衍生物,该化合物通过自组装能形成具有一定规则孔道的微观结构,具有包载功能.采用红外光谱、差热分析和扫描电子显微镜等对产物的结构、结晶态及微观形貌进行了表征,同时测试了其细胞毒性.用该化合物包载姜黄素及磁性纳米粒子,获得了具有磁靶向功能的载药体系,研究了载药体系的结晶态、微观形貌、热稳定性及磁学性能,并阐明了载药机制.

A novel amphiphilic cyclotriphosphazene derivative was synthesized and its properties including chemical composition, crystalline state, thermostability and micromorphology were systematically characterized by FTIR, DSC and SEM. Meanwhile, the cytotoxicity of the compound was also tested. The special micro-structure with abundant ducts based on the long hydrophilic chain PEG was formed by the cyclotriphosphazene derivative via a self-assembled process, these ducts could be utilized as vehicles for loading curcumin and magnetic Fe3 O4 nanoparticles. Furthermore, the micromorphology, crystalline state, thermostability and mag-netite properties of the fabricated drug delivery system were thoroughly investigated and the drug-loaded mechanism was revealed.