艾迪注射液联合卡铂胸腔灌注治疗恶性胸水的临床疗效

Clinical effect of intrapleural injection of carboplatin and aidi injection on malignant pleural effusion

目的：观察艾迪注射液联合卡铂胸腔内注射治疗恶性胸水的治疗效果。方法采用胸腔穿刺抽净胸水。观察组胸腔内每次注入艾迪注射液50 ml，卡铂粉针剂400 mg﹢5%葡萄糖40 ml胸腔灌注化疗，每周1次，抽净胸水后灌注，据胸水情况应用2~4次；对照组单纯应用卡铂胸腔灌注化疗，2个月后观察疗效和不良反应。结果观察组近期疗效、生活质量均明显优于对照组，不良反应明显少于对照组。结论艾迪注射液与卡铂联合胸腔灌注治疗恶性胸水可提高疗效，且不良反应轻。

Objective To observe the effect of intrapleural cavity perfusion with aidi-injection and carboplatin on malignant pleural effusion. Methods The pleural effusion was sucked by thoracentesis. Patients were given pleural perfusions chemotherapy with aidi-injection 50 ml and carboplatin 400 mg once a week in the observation group,and only carboplatin was given in the control group. The efficacy and adverse reactions were observed after 2 months. Results In the observation group,the short-term effect and quality-of-life was superior to that in the control group,and the side effects were obviously less than those in control group. Conclusions Pleural perfusion with carboplatin and aidi-injection can effectively improve the curative effect and reduce the drugs side-effects.