轮状病毒感染性腹泻病并发多器官功能损害临床治疗与体会

Clinical practice and experience of rotavirus infectious diarrhea disease complicated with multiple organ damage

目的：观察患儿发生轮状病毒感染腹泻并发多器官功能损害情况。方法回顾性分析80例轮状病毒感染性腹泻患儿感染状况与多器官损害（观察组）情况。患儿入院后，收集粪便标本作轮状病毒抗体测定，大便培养检查，检测血常规、血生化、心肌酶谱、肝肾功能、腹部X线、心电图。另选取同期入院36例轮状病毒感染腹泻无多器官损伤患儿为对照组，比较两组临床情况。结果观察组出现不同程度的呼吸系统症状、肝肾功能异常、心肌酶异常、神经系统功能受损，对照组发热、脱水、电解质紊乱情况较观察组明显减轻（P﹤0.05或P﹤0.01）。结论治疗轮状病毒感染腹泻时应注意肠外脏器功能损害，及早发现肠外脏器损害并积极治疗是防止轮状病毒感染性腹泻合并多器官功能损害的重要措施。

Objective To observe the rotavirus infectious diarrhea disease complicated with multiple organ damage in children. Methods The infection status of 80 children with rotavirus infectious diarrhea（ observation group ）and the multiple organ damage situation were retrospectively analyzed. The stool specimens were collected for detection of rotavirus antibody,stool culture was made,and blood routine,blood biochemistry,the myocardial enzyme spectrum,liver and kidney function,abdominal X-ray, electrocardiogram were detected. Thirty-six children with rotavirus diarrhea infection without multiple organ damage in the same period admitted in our hospital were chose as the control group,the clinical indicators were compared between the two groups. Results The children in observation group had different degrees of respiratory symptoms,liver and kidney dysfunction,abnormal myocardial enzymes,nervous system dysfunction. Compared with the observation group,the symptoms of fever,dehydration,electrolyte imbalance situation were alleviated obviously in the control group（ P ﹤0. 05 ,P ﹤0. 01 ）. Conclusions During the treatment of rotavirus infection diarrhea,parenteral viscera function damage should be paid attention to. Early detection and active treatment of parenteral viscera damage,is the important measure to prevent rotavirus infectious diarrhea combined with multiple organ damage.