铜催化芳硼酸与亚磷酸酯在空气下的有氧碳-磷氧化偶联反应

Copper-Catalyzed Aerobic Oxidative C—P Coupling of Arylboronic Acids and Diethyl Phosphite under Air

在Cu(OAc)2/TMEDA体系催化下,芳硼酸与亚磷酸二乙酯可在室温下以空气为直接氧化剂通过氧化偶联反应生成芳基膦酸酯化合物.该反应使用较为廉价低毒的铜盐为催化剂,不怕水、不怕氧,底物适用范围较广,目标产物选择性高、收率良好.因此,与已知金属催化卤代芳烃的碳-磷偶联反应相比是一种相对温和高效的合成芳基膦酸酯的方法.

By using Cu（OAc）2/TMEDA as the catalyst and air as the direct oxidant, arylboronic acids and diethyl phosphite can readily undergo an aerobic oxidative C--P coupling reaction under air at room temperature to give the useful arylphosphonates. This reaction uses relatively cheaper and less toxic copper salts as the catalyst, tolerates moisture and aerobic conditions, is suitable for a comparatively broad scope of substrates, and can give the target arylphosphonates in high selectivities and good yields. In comparison with conventional metal-catalyzed C--P coupling reactions of aryl halides, it is a relatively mild and efficient method for the synthesis of arylphosphonates.