摘要
以炔基溴和咪唑衍生物为反应原料,详细探讨了无过渡金属催化条件下的咪唑类芳香炔胺化合物的合成方法.研究结果表明,以N,N-二甲基甲酰胺为溶剂、碳酸钾为碱,于80℃下反应12 h即可获得中等偏上收率的碳-氮偶联产物.通过上述方法合成得到了系列芳香炔胺衍生物,其结构经1H NMR和13C NMR表征.
Transition-metal-free alkynylation of imidazoles with alkynyl bromides was examined in detail. With K2CO3 as base in N,N-dimethylformamide (DMF) at 80℃ for 12 h, the reaction afforded the corresponding carbon-nitrogen cross-coupling products in moderate yield. Imidazole-based aromatic ynamines were synthesized by the above method, and the structure was characterized by IH NMR and 13C NMR spectra.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2014年第7期1352-1357,共6页
Chinese Journal of Organic Chemistry
基金
黑龙江省教育厅科学技术研究(No.12533023)资助项目~~