CuBr_2催化的三组分反应合成喹啉-2,4-二羧基衍生物

CuBr_2-Catalyzed Three-Component Coupling for Synthesis of Quinoline-2,4-dicarboxyl Derivatives

以廉价的CuBr2为催化剂,发展了一种通过芳胺、乙醛酸酯与丙酮酸酯三组分反应制得喹啉-2,4-二羧基衍生物的简便有效方法.该方法具有很好的原子经济性,使用了便宜的催化剂和易得的试剂,在温和的条件下解决了以往喹啉-2,4-二羧基衍生物合成条件苛刻、产率低等问题,在生物活性分子和药物分子合成上有潜在的应用价值.

A convenient and efficient method for synthesizing quinoline-2,4-dicarboxyl derivatives has been developed via a simple one-pot reaction of aromatic amines, glyoxylic ester, and pyruvate using low-costing CuBr2 as a catalyst. The method is atom efficiency, and utilizes non-expensive catalysts and easily available reagents, which provides an attractive approach to quinoline-2,4-dicarboxyl derivatives. This process has potential applications in the synthesis of biologically and medicinally relevant compounds.