雷公藤多苷联合二甲双胍治疗糖尿病肾病临床观察

Clinical Observation on Tripterygium Glycosides and Metformin in Treating Diabetic Nephropathy

目的:探讨雷公藤多苷联合二甲双胍治疗糖尿病肾病(DN)的临床疗效。方法:将DN患者150例随机分为研究组(n=74)和对照组(n=76),对照组予二甲双胍治疗,研究组予雷公藤多苷+二甲双胍治疗,疗程6个月。评价2组患者空腹血糖(FPG)、餐后2h血糖(2 hPG)、收缩压(SBP)、舒张压(DBP)、24 h尿蛋白定量、尿白蛋白排泄率(UAE)、血肌酐(Ccr)和血尿素氮(BUN)改善情况。结果:上述各指标治疗后2组均明显下降,与治疗前比较差异具有统计学意义(P<0.05),治疗后2组FPG、2hPG、SBP和DBP比较差异无统计学意义(P>0.05),但24小时尿蛋白定量、UAE、Ccr和BUN比较差异具有统计学意义(P<0.05)。结论:雷公藤多苷联合二甲双胍治疗DN,能明显降低患者尿蛋白含量,改善肾功能,并能从根本上改善血压和血糖指标。

Objective： To explore therapeutic effects of tripterygium glycosides and metformin in treating dia-betic nephropathy （DN）. Methods： All 150 DN patients were randomly separated into the study group （n=74） and the control group （n=76）. The control group took metformin, the study group tripterygium glycosides and metformin, all the patients were treated for six months. Fasting plasma glucose （FPG）, 2 hour postprandial glucose （2hPG）, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, 24h urine protein, urinary albumin excretion （UAE）, serum creatinine （Scr） and blood urea nitrogen （BUN） of the patients in both groups were assessed. Results： After treating, all the indexes of both groups were decreased remarkably, the difference presented statistical meaning compared with before treating （P0.05）, but the difference demonstrated statistical meaning in 24h urine protein, UAE, Scr and BUN after treating between both group （P〈0.05）. Conclusion： Tripterygium glycosides and metformin in treating DN could obviously decrease the contents of urine protein, improve renal function, blood pressure and the indexes of glucose completely.