α_1、β_2微球蛋白在原发性高血压早期肾损害中的临床意义

Clinical Significances of α_1-microglobulin and β_2-microglbulin in Early Renal Injury of the Patients Suffering from Essential Hypertension

目的:探讨联合检测血、尿α1微球蛋白(α1-MG)、β2微球蛋白(β2-MG)在原发性高血压(EH)早期肾损害中的临床意义。方法:将55例原发性高血压患者按Ccr<85 mL/min和85 mL/min<Ccr<110 mL/min分为A(26)、B(29)2个亚组,另选健康体检者60例作为正常对照组,用免疫比浊法测定血、尿α1、β2微球蛋白的含量。结果:A组患者血、尿α1、β2微球蛋白含量均较对照组显著升高(P<0.01);B组患者血、尿β2微球蛋白与对照组比较无显著性差异(P>0.05),而血、尿α1微球蛋白与对照组比较有显著性差异(P<0.05);B组与A组比较血、尿α1、β2微球蛋白差异有统计学意义(P<0.05)。结论:联合检测血、尿α1微球蛋白(α1-MG)、β2微球蛋白(β2-MG)能够较好地反映原发性高血压肾损伤的病情程度,对其早期诊断具有重要临床应用价值。

Objective： To explore clinical significance of detectingα1-microglobulin （α1-MG） andβ2-mi-croglbulin （β2-MG） in early renal injury of the patients with essential hypertension （EH）. Methods： Fifty-five patients were divided into group A （26 cases） and group B （29 cases） according to Ccr0.05）, it had significant difference in the contents ofα1-MG in the blood and urine when group B was compared with the control group（P〈0.05）; the difference showed statistical meaning when group B was com-pared with group A in the contents ofα1-MG andβ2-MG in the blood and urine （P〈0.05）. Conclusion： Combination detection ofα1-MG andβ2-MG in the blood and urine could reflect the degree of early renal injury of EH patients, and the detection shows important clinical value in early diagnosis.