老年帕金森病轻度认知损害患者踝臂指数、超敏C反应蛋白的临床研究

Clinical Study of Ankle-Brachial Index and High-Sensitivity C-Reactive Protein in Elderly Patients with Parkinson's Disease and Mild Cognitive Impairment

目的探讨踝臂指数(ABI)、血清超敏C反应蛋白(hs-CRP)与老年帕金森病合并轻度认知损害(PD-MCI)的关系。方法 89例老年帕金森病患者,其中合并轻度认知损害43例(PD-MCI组),无合并轻度认知损害46例(单纯PD组),健康对照组46例,采用全自动动脉硬化BP203RPE-II检测仪检测各组对象ABI,采用酶比色法测定血清hs-CRP水平。结果 PD-MCI组、单纯PD组患者ABI均低于对照组(P<0.05),PD-MCI组与单纯PD组ABI比较,差异无统计学意义(P>0.05)。PD-MCI组hs-CRP水平高于对照组、单纯PD组(P<0.05),单纯PD组hs-CRP水平与对照组比较,差异无统计学意义(P>0.05)。结论老年帕金森病患者ABI下降,PD-MCI患者血hs-CRP水平升高。hs-CRP水平升高可能是反映PD-MCI的指标。

Objective To study the relationship between ankle-brachial index（ ABI）,serum high-sensitivity C-reactive protein（ hs-CRP） and elderly Parkinson＇s disease with mild cognitive impairment（ PD-MCI）. Methods Eighty-nine cases of elder Parkinson＇ s disease were divided into 2 groups： 43 cases with mild cognitive impairment（ PD-MCI group） and 46 cases without mild cognitive impairment（ pure PD group）,respectively. Forty-six cases of the healthy elders were selected as control group. ABI of all observers was detected by full-automatic arteriosclerosis（ BP203RPE-Ⅱ）,and serum hs-CRP level was examined by enzyme colorimetry. Results The ABI in the PD-MCI group,pure PD group was lower than that in the control group（ P〈0. 05）. The ABI showed no significant difference between PD-MCI group and pure PD group（ P〉0. 05）. The hs-CRP level in the PD-MCI group was higher than that in the control group or pure PD group（ P〈0. 05）,while the hs-CRP level showed no significant difference between pure PD group and control group（ P〉0. 05）. Conclusion Lower ABI can be observed in elderly patients with Parkinson＇s disease. The hs-CRP level increases in PD-MCI patients,which indicates the increase of hs-CRP level may be an index of PD-MCI.