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寻常型银屑病患者IL-22水平的变化及其临床意义 被引量：9

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摘要 目的探讨寻常型银屑病患者血清IL-22水平与银屑病面积和严重程度指数(PASI)及治疗转归的关系。方法应用ELISA检测39例寻常型银屑病患者及51例正常对照的血清IL-22水平,比较两组血清IL-22水平的差异,评估银屑病患者IL-22水平与PASI之间的关系并对比治疗前后的变化。结果病例组治疗前血清IL-22的水平较对照组高(t′=8.578,P<0.01),且与PASI呈正相关(r=0.64,P<0.05)。治疗4周及8周后血清IL-22均较治疗前下降(q=6.994,P<0.05;q=9.501,P<0.05),PASI变化也表现了同样的趋势(q=36.27,48.26,P<0.05)。结论 IL-22在寻常型银屑病的发病中可能起重要作用,其血清水平可作为疾病严重程度以及疗效评估的指标之一。
作者 刘军麟 邹循辉 殷梅
机构地区 海南省农垦总医院皮肤科 广东省惠州市皮肤病医院皮肤科 海南省农垦总医院体检中心
出处 《重庆医学》 CAS CSCD 北大核心 2014年第21期2809-2810,2829,共3页 Chongqing medicine
关键词 白细胞介素22 酶联免疫吸附法 寻常型银屑病 银屑病面积 严重程度指数
分类号 R758.63 [医药卫生—皮肤病学与性病学]
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二级参考文献10

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同被引文献69

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引证文献9

二级引证文献38

重庆医学
2014年 第21期

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