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单侧输尿管梗阻模型引起肾损伤的新认知及进展 被引量：4

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摘要 单侧输尿管梗阻(UUO)是研究急性肾损伤(AKI)和慢性肾脏病(CKD)的一种常见实验模型,该模型不能评估肾脏功能的整体变化,但对降低病死率和监测对侧肾功能变化起作用。本文就各类型肾损伤中发生间质性炎、细胞坏死及纤维化等病理过程的分子机制通过UUO模型进行阐明,主要阐述了引起肾损伤的一些关键性因子,并提出了一些新的干预性的治疗靶向;此外,还介绍了间充质干细胞(MSCs)对肾损伤的修复作用。
作者 邢健生 白志明
机构地区 中南大学湘雅医学院附属海口医院泌尿外科
出处 《海南医学》 CAS 2014年第13期1964-1967,共4页 Hainan Medical Journal
关键词 单侧输尿管梗阻 肾损伤 靶向治疗 间充质干细胞
分类号 R692 [医药卫生—泌尿科学]
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参考文献47

  • 1Yoo KH, Thornhill BA, Forbes MS, et al. Osteopontin regulates re- nal apoptosis and interstitial fibrosis in neonatal chronic unilateral ureteral obstruction [J]. Kidney Int, 2006, 70(10): 1735-1741.
  • 2Meldrum KK, Metcalfe P, Leslie JA, et al. TNF-alpha neutralization decreases nuclear factor-kappaB activation and apoptosis during re- nal obstruction [J]. J Surg Res, 2006. 131(2): 182-188.
  • 3Sanz. NF-kappaB in renal inflammation [J]. J Am Soc Nephrol, 2010, 21(8): 1254-1262.
  • 4Le Meur Y, Tesch GH, Hill PA, et al. Macrophage accumulation at a site of renal inflammation is dependent on the M-CSF/c-fms path- way [J]. J Leukoc Biol, 2002, 72(3): 530-537.
  • 5Ricardo SD, van Goor H, Eddy AA. Eddy, Macrophage diversity in renal injury and repair [J]. J Clin Invest, 2008, 118(11): 3522-3530.
  • 6Pindjakova J, Hanley SA, Duffy MM. et al. Interleukin-1 accounts for intrarenal Th17 cell activation during ureteral obstruction [J]. Kidney Int, 2012, 81(4): 379-390.
  • 7Gao B, Waisman A. Waisman, Th17 cells regulate liver fibrosis by targeting multiple cell types: many birds with one stone [J]. Gastro- enterology, 2012, 143(3): 536-539.
  • 8Tan HL, Regamey N, Brown S, et al. The Th17 pathway in cystic fi- brosis lung disease [J]. Am J Respir Crit Care Med, 2011, 184(2): 252-258.
  • 9Ardura JA, Berruguete R, Ramila D, et al. Parathyroid hormone-re- lated protein interacts with vascular endothelial growth factor to pro- mote fibrogenesis in the obstructed mouse kidney [J]. Am J Physiol Renal Physiol, 2008, 295(2): F415-425.
  • 10Degterev A, Huang Z, Boyee M, et al. Chemical inhibitor of non- apoptotic cell death with therapeutic potential for ischemic brain in- jury [J]. Nat Chem Biol, 2005, 1(2): 112-119.

二级参考文献23

  • 1杨靖,王庆海,曾秋棠,毛晓波.人骨髓间充质干细胞对同种异体调节性T细胞的影响及可能机制实验研究[J].中国实验血液学杂志,2007,15(4):785-789. 被引量：10
  • 2WAN J X, ZOU Z H, YOU D Y, et al. Bone marrow - derived mesenchymal stem cells differentiation into tubular epithelial - like cells in vitro[ J]. Cell Biochem Funct, 2012, 30(2) : 129 - 138.
  • 3TOGEL F, ZHANG P, HU Z, et al. VEGF is a mediator of the renoprotective effects of muhipotent marrow stromal cells in acute kidney injury[ J1. Cell Mol Med, 2009, 13(8B) : 2109 -2114.
  • 4NANGAKU M, ALPERS C E, PIPPIN J, et al. CD59 protects glomerular endothelial cells from immune - mediated thrombotic microangiopathy in rats [ J ]. J Am Soc Nephrol, 1998, 9 (4) : 590 - 597.
  • 5STACCHIOTI'I A, BORSANI E, RODELLA L, et al. Dose- de- pendent mercuric chloride tubular injury in rat kidney [ J J. U1- trastruct Pathol, 2003, 27(4): 253-259.
  • 6KANG K P, PARK S K, KIM D H, et al. Luteolin ameliorates eisplatin- induced acute kidney injury in mice by regulation of p53 -dependen renal tubular apoptosis [ J ]. Nephrol Dial Trans-plant, 2011, 26(3) : 814 -822.
  • 7HERRERA M B, BUSSOLATI B, BRUNO S, et al. Exogenous mesenchymal stem cells localize to the kidney by means of CD44 following acute tubular injury [ J ]. Kidney Int, 2007, 72 ( 4 ) : 430 - 441.
  • 8ROGERS N M, STEPHENSON M D, KITCHING A R, et al. A- melioration of renal ischaemia - reperfusion injury by liposomal de- livery of curcumin to renal tubular epithelial and antigen presenting cells[J]. Br J Pharmacol, 2012, 166( 1 ) : 194 -209.
  • 9BUSSOLATI B, BRUNO S, GRANGE C, et al. Isolation of renal progenitor cells from adult human kidney[J]. Am J Pathol, 2005, 166(2) : 545 -555.
  • 10MORIGI M, INTRONA M, IMBERTI B, et al. Human bone mar- row mesenchymal stem cells accelerate recovery of acute renal inju- ry and prolong survival in mice [ J ]. Stem Cells, 2008, 26 (8) : 2075 - 2082.

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海南医学
2014年 第13期

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