臭氧浓度对介入再通术治疗输卵管阻塞性不孕症的影响

Influence of ozone concentration on the effect of interventional recanalization in the treatment of tubal obstructive infertility

目的：探讨在臭氧联合介入再通术治疗输卵管阻塞性不孕症中不同臭氧浓度对治疗效果的影响。方法200例输卵管阻塞性不孕症患者均分为四组（A、B、C、D）各50例，A组接受常规输卵管再通术治疗，B组、C组、D组行臭氧联合输卵管再通术治疗，其中B组为低浓度臭氧（20μg/ml），C组为中浓度臭氧（40μg/ml），D组为高浓度臭氧（60μg/ml）。对所有患者术后2周内出现的不适症状进行评分。所有患者于6个月后均随访检查，记录宫内妊娠率，并对未妊娠者行输卵管造影，记录输卵管再闭塞率。结果四组的不适症状评分分别为（2.900±1.418）分、（2.140±1.246）分、（2.120±1.272）分、（2.700±1.359）分，差异有统计学意义（P〈0.05），其中A组和B组、A组和C组、B组和D组、C组和D组的组间差异有统计学意义（P〈0.05），A组和D组、B组和C组的组间差异均无统计学意义（P〉0.05）。四组的妊娠率分别为28.00%（14/50）、42.00%（21/50）、50.00%（25/50）、54.00%（27/50），整体差异有统计学意义（P〈0.05），其中A组和C组、A组和D组的组间差异有统计学意义（P〈0.05），A组和B组、B组和C组、B组和D组、C组和D组的组间差异均无统计学意义（P〉0.05）。四组的再闭塞率分别为25.68%（19/74）、14.29%（10/70）、11.27%（8/71）、8.57%（6/70），整体差异有统计学意义（P〈0.05），其中A组和C组、A组和D组的组间差异有统计学意义（P〈0.05），A组和B组、B组和C组、B组和D组、C组和D组的组间差异均无统计学意义（P〉0.05）。结论医用臭氧能提高介入性输卵管再通术在不孕症中的治疗效果，宜首选中等浓度（30~50μg/ml）臭氧进行治疗。

Objective To discuss the influence of different concentrations of ozone on the effect of interven-tional recanalization in the treatment of infertility with tubal obstructive. Methods Two hundred patients with tubal obstruction infertility were divided into 4 groups （A, B, C, D） equally. Group A received conventional fallopian tube recanalization therapy. The other groups （B, C, D） received ozone combined with fallopian tube recanalization thera-py. Group B, Group C and Group D were given low concentration of ozone （20 μg/ml）, moderate concentration of ozone （40μg/ml）, and high concentration ozone （60 μg/ml） respectively. Discomforts occurring within 2 weeks after operation were scored. And after 6 months of follow-up, the intrauterine pregnancy rate was recorded, meanwhile, tub-al reocclusion rate of non-pregnancy women were documented after tubal radiography. Results Scores of discom-forts in four groups were （2.900 ± 1.418）, （2.140 ± 1.246）, （2.120 ± 1.272）, and （2.700 ± 1.359） respectively, and there were differences between group A and group B, group A and group C, group B and group D, group C and group D （P〈0.05）. However, there was no significant difference between group A and group D, group B and group C （P〉0.05）. The pregnancy rates of four groups were 28.00%（14/50）, 42.00%（21/50）, 50.00%（25/50） and 54.00%（27/50） respective-ly, and there were differences between group A and group C, group A and group D （P〈0.05）, however, there was no significant difference between group A and group B, group B and group C, group B and group D, group C and group D （P〉0.05）. The reocclusion rate were 25.68%（19/74）, 14.29%（10/70）, 11.27%（8/71）, and 8.57%（6/70）, and there were differences between group A and group C, group A and group D （P〈0.05）, however, there was no significant dif-ference between group A and group B, group B and group C, group B and group D, group C and group D （P〉0.05）. Conclusion Medical ozone can improve the effect of interventional fallopian tube recanalization in the treatment of infertility, and a moderate concentration （30~50μg/ml） of ozone is regarded as the first choice.