内镜下套扎术及药物治疗食管胃底静脉曲张出血的有效性及安全性综合评价

Evaluation of effectiveness and safety of esophageal variceal ligation combined drug for esophageal and gastric varicose bleeding

目的观察并评价内镜下套扎术(Esophageal variceal ligation,EVL)联合药物治疗食管胃底静脉曲张出血(BEGV)的有效性及安全性。方法选取2011年5月至2012年9月笔者所在医院接诊的112例BEGV患者,按照治疗方式的不同将患者分成观察组和对照组各56例。观察组患者接受内镜下EVL术联合药物治疗,而对照组患者仅接受药物治疗。所有患者均随访一年,统计患者的治疗效果及不良反应发生的情况。结果观察组患者食管胃底静脉曲张消失、止血成功和BEGV复发例数分别为53例、55例和3例,对照组分别为42例、46例和11例;观察组不良反应发生率为5.4%,对照组为28.6%;上述各项指标比较差异均具有统计学意义(P<0.05)。结论 EVL联合药物治疗BEGV疗效显著,且安全可靠,值得临床上进一步推广应用。

Objective To observe and evaluate the effectiveness and safety of esophageal variceal ligation （EVL） combined drug for esophageal and gastric varicose bleeding （EGVB）. Methods A total of112 cases of EGVB in our hospital from May 2011 to September 2012 were selected and divided into observation group and control group according to the different treatment methods. The observation group received EVL combined with drug therapy, while the control group received drug treatment only. All the patients were followed up for 1 year, and then the therapeutic effect and adverse reactions were recorded. Results The number of patients with disappeared EGVB, successful he-mostasis and EGVB recurrence in the observation group were 53, 55 and 3 respectively, which in the control group were 42, 46 and 11 respectively. Incidence of adverse reactions in the observation group and the control group were 5.4%and 28.6%respectively, with statistically significant different （P〈0.05）. Conclusion EVL combined with drug therapy has a significant effect on treatment for BEGV with good safety and reliability. Therefore, it＇s worthy of fur-ther clinical application.