抗菌肽——一类新型抗肿瘤药物

Antimicrobial Peptides:A Novel Antitumor Agent

化疗是肿瘤治疗的重要手段之一,其严重的副作用影响其在临床上的广泛应用。同时,肿瘤细胞的耐药现象也是化疗失败的主要原因之一。因此,开发新型抗肿瘤药物是当前研究热点之一。抗菌肽是先天免疫系统的重要组分,部分抗菌肽表现出高选择性的抗肿瘤活性,并且其特殊的作用机制避免肿瘤细胞耐药的发生。因此,抗菌肽可作为一类新型抗肿瘤药物。

Chemotherapy is a major strategy for cancer therapy ;however, the severe side effects restrain its clini; cal application. Meanwhile, drug resistance of tumor cells is another reason for the failure of cancer chemotherapy. Therefore,the development of novel antitumor agents become the focus of the recent antitumor research. Antimicrobial peptides are significant components in innate immune system, some of them present selective antitumor activity, and the unique mechanism of action circumvent the drug resistance of tumor cells. Thus, antimicrobial peptides might be promising candidates for cancer therapy.